Survey of IgE Reactivity to Nonbiting Midges in Korea and Identification of IgE-Binding Protein

Allergy, Asthma & Immunology Research
Myung Hee YiTai Soon Yong

Abstract

Chironomids (nonbiting midges) are widely and abundantly distributed near ponds, rivers, and artificially dammed pools used for irrigation. Chironomids contain allergens and cause airway allergy in humans. In this study, we aimed to examine the allergic potential of chironomids in inhabitants living near artificially dammed pools. We examined immunoglobulin E (IgE) reactivity to chironomid extracts in the sera of residents living around installed dams and assessed the correlations of IgE responses between chironomids (Chironomus flaviplumus, Chironomus kiiensis, Cricotopus bicinctus) and house dust mites (Dermatophagoides farinae). In addition, we identified potential IgE binding proteins specific for adult C. bicinctus, a popular species in Korea. Specific IgE antibodies in sera collected from the participants against the extracts were tested using enzyme-linked immunosorbent assay (ELISA). The average IgE-positive rates were 10.4%, 8.1%, and 8.2% in C. bicinctus, C. flaviplumus, and C. kiiensis, respectively. The IgE-positive rate and IgE titer of C. bicinctus antigen were higher in residents living around installed dams than in those who lived other places (P = 0.013). Western blotting using sera having high IgE titers to C....Continue Reading

References

Oct 1, 1995·International Archives of Allergy and Immunology·A M WittemanR C Aalberse
Sep 4, 1999·International Archives of Allergy and Immunology·G ReeseS B Lehrer
Feb 23, 2008·Advances in Food and Nutrition Research·Steve L Taylor
Feb 15, 2011·Annual Review of Biophysics·Roberto Dominguez, Kenneth C Holmes
Jan 2, 2015·Allergy, Asthma & Immunology Research·Angela María CandrevaSilvana Petruccelli

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
electrophoresis

Software Mentioned

Score Sequest HT
SPSS Statistics

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