Survey of nonsusceptible nasopharyngeal Streptococcus pneumoniae isolates in children attending day-care centers in Brazil.

The Pediatric Infectious Disease Journal
Cáritas M FrancoMaria-Cristina de Cunto Brandileone

Abstract

A survey of nasopharyngeal carriage of penicillin nonsusceptible pneumococcal (PNSp) isolates was conducted among 1192 children attending 62 day care centers in Brazil, where pneumococcal vaccination has not been routinely introduced. Nasopharyngeal pneumococcal carriage was detected in 686 (57.6%) infants, and 178 (25.9%) of them carried PNSp isolates. Being less than 24 months of age, hospitalization in the previous 3 months, and recurrent acute otitis media were independently associated with PNSp. Serotypes 14, 23F, 19A, 6A, 6B and 19F were the most common serotype isolated accounting for 80% of the PNSp. A high proportion (35/332) of non-(sero)typeable isolates was detected, 62.9% of them PNSp. Serotypes coverage projected for the pneumococcal conjugate vaccine (PCV) 13-valent vaccine (72%) was significantly higher compared with PCV7 (58.4%) and PCV 10-valent vaccine (59.3%).

References

Feb 15, 2003·The Pediatric Infectious Disease Journal·Katherine L O'BrienUNKNOWN World Health Organization Pneumococcal Vaccine Trials Carriage Working Group
Jun 12, 2003·The Pediatric Infectious Disease Journal·Eugene LeibovitzRon Dagan
Mar 5, 2004·The Lancet Infectious Diseases·D BogaertP W M Hermans
Feb 8, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C B LavalM C C Brandileone
Aug 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip C HillRichard A Adegbola
Jan 19, 2008·Journal of Medical Microbiology·J YuM H Nahm

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Citations

Feb 15, 2012·Vaccine·Jae-Hoon SongBernard Fritzell
Sep 16, 2011·Vaccine·Ana Lucia AndradeJoão Guimarães Andrade
Nov 13, 2010·Journal of Medical Microbiology·Malek RachdiSaida Ben Redjeb
Jan 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Serena DonatiUNKNOWN Regional Maternal Mortality Working Group
Jan 31, 2012·Journal of Medical Microbiology·Juliana Lamaro-CardosoAna Lucia Andrade

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