Survey of the use of domperidone and the association with QTc prolongation in general practice

Postgraduate Medical Journal
Adam IoannouConstantinos Missouris

Abstract

Domperidone is associated with QTc prolongation, predisposing to the development of ventricular arrhythmias. In 2014, The Medicines and Healthcare Regulatory Agency (MHRA) recommended restricting its use. We assessed whether these recommendations have been implemented in a general practice. We conducted a prospective study using the general practitioner (GP) computer database on patients who had at least one repeat prescription for domperidone in 12 months. Data were presented to the doctors and the survey was repeated 7 months later. Sixty-four patients (mean age 61.3±16.4 years) were identified who had received at least one repeat prescription of domperidone. Twenty patients were being prescribed over the recommended daily dose. Nineteen patients were coprescribed medications known to prolong the QTc interval and two CYP3A4 inhibitors. The repeat survey performed 7 months later demonstrated a 70% reduction in the number of patients prescribed domperidone to a total of 19 (three patients prescribed above the recommended dose) none of which had a history of cardiac disease or were being coprescribed drugs known to prolong the QTc interval. Following the publication of the MHRA recommendations and presentation of our initial sur...Continue Reading

References

Nov 5, 2003·Heart·Yee Guan Yap, A John Camm
Apr 29, 2006·Journal of Cardiovascular Electrophysiology·Ilan GoldenbergWojciech Zareba
Oct 23, 2008·The Journal of Pediatrics·Kathryn K Collins, Judith M Sondheimer
Oct 12, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Charlotte van NoordMiriam C J M Sturkenboom
Sep 12, 2013·Current Medical Research and Opinion·Katy E TrinkleyJames E Tisdale

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Citations

Aug 23, 2019·International Journal of Environmental Research and Public Health·Kiyon RhewJung Mi Oh

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