Survival Advantage of Yttrium-90 Radioembolization to Systemic Therapy in Patients with Hepatic Metastases from Colorectal Cancer in the Salvage Setting: Results of a Matched Pair Study.

Academic Radiology
Zachary HaberSiddharth A Padia

Abstract

Patients with hepatic metastases from colorectal cancer have a poor prognosis in the salvage setting. This study assessed the survival benefit of adding transarterial 90Y radioembolization in the salvage setting to systemic therapy. In this retrospective, matched-pair study, 21 patients who underwent radioembolization plus systemic therapy were matched with a cohort of 173 patients who received systemic chemotherapy alone in the salvage setting, defined as progression on at least two different regimens of systemic chemotherapy. Patients were matched one-to-one on Eastern Cooperative Oncology Group Performance Status, presence of extrahepatic disease, and presence of tumor KRAS mutation. Radioembolization patients underwent treatment using standard dosimetry to either a hepatic lobe or the whole liver. Survival data was analyzed using Kaplan-Meier analysis. Patients who underwent radioembolization plus systemic therapy vs. those who had systemic therapy alone had similar demographics and exposure to prior systemic chemotherapies. Median survival from the date of primary diagnosis was 38 (95% CI 26 to 50) v 25 (95% CI 15 to 35) months in radioembolization with systemic therapy vs. systemic therapy alone (p = 0.17). Median surviva...Continue Reading

References

Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Axel GrotheyHans-Joachim Schmoll
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan D RichmanPhilip Quirke
Jul 16, 2010·British Journal of Cancer·M CosimelliUNKNOWN Italian Society of Locoregional Therapies in Oncology (SITILO)
Jan 27, 2012·Clinical Colorectal Cancer·Ludmila Katherine MartinTanios Bekaii-Saab
Jun 8, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Robert J LewandowskiRiad Salem
Aug 15, 2014·Frontiers in Oncology·Mihir RavalSanjeeva P Kalva
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marwan G Fakih
Sep 30, 2015·Cancer Treatment Reviews·René AdamUNKNOWN of the EGOSLIM (Expert Group on OncoSurgery management of LIver Metastases) group
Feb 11, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CremoliniA Falcone
May 15, 2018·Journal of Vascular and Interventional Radiology : JVIR·Ashley A WeinerParag J Parikh
May 6, 2020·Cardiovascular and Interventional Radiology·Alexander DabrowieckiNima Kokabi
Apr 1, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C J H van de Velde

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