Survival after AIDS among Italian haemophiliacs with HIV infection. The Italian Group on Congenital Coagulopathies

AIDS
A GhirardiniF Chiarotti

Abstract

To estimate survival trends for persons with haemophilia and HIV/AIDS. Survival analysis conducted among the cohort of HIV-positive haemophiliacs with AIDS at the Italian Haemophilia Registry. Kaplan-Meier method was used to estimate survival times, stratifying for demographic and clinical covariates. Cox proportional hazards model was applied in order to identify factors independently associated with survival. Median survival from the first AIDS diagnosis to death was estimated to be 17.0 months for 176 individuals with AIDS. Median survival after AIDS diagnosis increased from 12.0 months in December 1983-December 1988 to 17.0 months in January 1989-May 1990 and to 25.0 months in June 1990-December 1991. Median survival times were significantly (P < 0.001) lower for individuals diagnosed with non-infective AIDS indicator diseases (lymphoma, AIDS-associated neurological disease, Kaposi's sarcoma, wasting syndrome: 4.0 months), in comparison with haemophiliacs diagnosed with Pneumocystis carinii pneumonia (PCP; 18.0 months) or other infections (35.0 months). Antiretroviral treatment after AIDS diagnosis was associated with a longer survival than that estimated for individuals with no treatment after AIDS; the same was true for P...Continue Reading

Citations

Sep 10, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·G TouloumiA Hatzakis
Aug 29, 2000·Sexually Transmitted Infections·D MorganJ A Whitworth
Aug 12, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J W HayC M Kessler
Jul 1, 2007·Current Opinion in HIV and AIDS·Linda-Gail BekkerRobin Wood
Jul 20, 2002·Revista de saúde pública·Maria F GuerreiroIusta Caminha
Feb 15, 2001·Nature Medicine·D Morgan, J Whitworth

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