PMID: 9165572Apr 1, 1997Paper

Survival after high-dose intraperitoneal infusion of glycine solution in the mouse

Scandinavian Journal of Urology and Nephrology
J OlssonR G Hahn

Abstract

We used an animal model to study whether glycine prompts death after absorption of irrigating fluid by the extravascular route. Mice were divided into groups of 10 and given an intraperitoneal infusion of 200, 225, 250, 275 or 300 ml/kg of glycine 1.1%, 1.5% or 2.2%. With all infused volumes, the chance of survival was better after infusion of glycine 1.1% and glycine 1.5% than after glycine 2.2%. The overall death rates were 10%, 16% and 46%, respectively. Logistic regression analysis showed that the outcome was significantly and independently affected by both the glycine concentration and the infused volume. We conclude that the glycine concentration of an irrigating fluid deposited in the peritoneal cavity is important to the chance of survival. The poorest chance is obtained with glycine 2.2%.

References

Jan 1, 1989·Paediatric and Perinatal Epidemiology·T BjerkedalD W Hosmer
Feb 1, 1989·The Journal of Surgical Research·G T BernsteinR F Gittes
Mar 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S WeberB I Kirimli
Sep 1, 1965·The Journal of Urology·S A MahoneyL Persky
Jul 1, 1995·The Journal of Urology·J OlssonR G Hahn
Jan 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R G Hahn
Jan 1, 1993·Scandinavian Journal of Urology and Nephrology·R G Hahn
Sep 1, 1995·Scandinavian Journal of Urology and Nephrology·W Zhang, R G Hahn
Feb 1, 1996·British Journal of Urology·W B Zhang, R G Hahn
Nov 1, 1957·The Journal of Urology·K B CONGER, L KARAFIN
Jun 1, 1948·The Journal of Urology·R M NESBIT, S I GLICKMAN

❮ Previous
Next ❯

Citations

Jan 25, 2006·Acta Anaesthesiologica Scandinavica·R G Hahn
Dec 1, 2005·British Journal of Anaesthesia·R G Hahn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.