Survival after hypofractionation in glioblastoma: a systematic review and meta-analysis.

Radiation Oncology
Jane-Chloe TroneEdouard Ollier

Abstract

Glioblastoma multiforme (GBM) has a poor prognosis despite a multi modal treatment that includes normofractionated radiotherapy. So, various hypofractionated alternatives to normofractionated RT have been tested to improve such prognosis. There is need of systematic review and meta-analysis to analyse the literature properly and maybe generalised the use of hypofractionation. The aim of this study was first, to perform a meta-analysis of all controlled trials testing the impact of hypofractionation on survival without age restriction and secondly, to analyse data from all non-comparative trials testing the impact of hypofractionation, radiosurgery and hypofractionated stereotactic RT in first line. We searched Medline, Embase and Cochrane databases to identify all publications testing the impact of hypofractionation in glioblastoma between 1985 and March 2020. Combined hazard ratio from comparative studies was calculated for overall survival. The impact of study design, age and use of adjuvant temozolomide was explored by stratification. Meta-regressions were performed to determine the impact of prognostic factors. 2283 publications were identified. Eleven comparative trials were included. No impact on overall survival was evid...Continue Reading

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Citations

May 1, 2021·Journal of Personalized Medicine·Valentina BravatàGiorgio Russo
Jun 25, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Ruichong MaPuneet Plaha
Jan 26, 2022·Radiation Oncology·Kelly J McKelveyViive M Howell

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Methods Mentioned

BETA
surgical resection
surgical
biopsy

Software Mentioned

R

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