Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis

European Journal of Anaesthesiology
Martin BellgardtAndreas Meiser

Abstract

Isoflurane has shown better control of intensive care sedation than propofol or midazolam and seems to be a useful alternative. However, its effect on survival remains unclear. The objective of this study is to compare mortality after sedation with either isoflurane or propofol/midazolam. A retrospective analysis of data in a hospital database for a cohort of consecutive patients. Sixteen-bed interdisciplinary surgical ICU of a German university hospital. Consecutive cohort of 369 critically ill surgical patients defined within the database of the hospital information system. All patients were continuously ventilated and sedated for more than 96 h between 1 January 2005 and 31 December 2010. After excluding 169 patients (93 >79 years old, 10 <40 years old, 46 mixed sedation, 20 lost to follow-up), 200 patients were studied, 72 after isoflurane and 128 after propofol/midazolam. Sedation with isoflurane using the AnaConDa system compared with intravenous sedation with propofol or midazolam. Hospital mortality (primary) and 365-day mortality (secondary) were compared with the Kaplan-Meier analysis and a log-rank test. Adjusted odds ratios (ORs) [with 95% confidence interval (95% CI)] were calculated by logistic regression analyses...Continue Reading

References

Jan 1, 1992·Intensive Care Medicine·E M Spencer, S M Willatts
May 13, 1989·BMJ : British Medical Journal·K L KongC Prys-Roberts
May 1, 1993·Anesthesiology·J H ArnoldJ A Molengraft
May 18, 2000·The New England Journal of Medicine·J P KressJ B Hall
Feb 21, 2003·British Journal of Anaesthesia·A MeiserH J Laubenthal
Oct 8, 2003·Critical Care Medicine·Amit BediJ P Howard Fee
Jan 11, 2005·Critical Care Medicine·Peter V SackeyPeter J Radell
Dec 16, 2010·The Journal of Pharmacy and Pharmacology·Jifeng Feng, Zhiyi Zuo
Feb 24, 2011·Acta Anaesthesiologica Scandinavica·J HellströmP V Sackey
Jul 2, 2011·Seminars in Cardiothoracic and Vascular Anesthesia·Mehrdad AsgeriNader D Nader
Jul 5, 2011·Acta Neurochirurgica. Supplement·Paul R GiganteE Sander Connolly
Oct 16, 2012·Critical Care : the Official Journal of the Critical Care Forum·Marc P SteurerBeatrice Beck-Schimmer
Dec 28, 2012·Critical Care Medicine·Juliana BarrUNKNOWN American College of Critical Care Medicine
Jan 25, 2013·Intensive Care Medicine·Yahya ShehabiUNKNOWN Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators
Jul 23, 2013·Anesthesiology·Inge K HerrmannBeatrice Beck-Schimmer
Oct 23, 2013·Critical Care Medicine·Jan HellströmPeter V Sackey

❮ Previous
Next ❯

Citations

Sep 23, 2016·Journal of Neurosurgical Anesthesiology·Timothy P DeYoungWilliam A Kofke
Nov 11, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai VerkoyenJustyna Swol
Jun 3, 2016·European Journal of Anaesthesiology·Martin BellgardtAndreas Meiser
Jun 9, 2016·European Journal of Anaesthesiology·Xiaojin Li, Rurong Wang
Sep 18, 2020·Journal of Intensive Care Medicine·Jochen MeyburgNavina Kuss
Jul 10, 2016·Journal of Clinical Monitoring and Computing·Hagen BombergAndreas Meiser
Feb 2, 2017·Der Anaesthesist·A MeiserH V Groesdonk
Mar 7, 2018·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Axel RandUwe Hamsen
Sep 2, 2017·Journal of Clinical Monitoring and Computing·Jennifer Herzog-NiesceryMartin Bellgardt
Aug 18, 2017·Critical Care Medicine·James M Blum, Robert F Groff
Jan 18, 2019·Journal of Clinical Monitoring and Computing·Jan Fa HendrickxStanley A Skinner
Jul 5, 2016·Intensive Care Medicine·Brian O'Gara, Daniel Talmor
Dec 12, 2017·International Anesthesiology Clinics·Ameeka Pannu, Brian O'Gara
Jun 17, 2018·Journal of Clinical Monitoring and Computing·Jan HendrickxAndre De Wolf
Nov 4, 2017·Journal of Clinical Monitoring and Computing·Panumart Manatpon, W Andrew Kofke
Nov 3, 2020·Critical Care Explorations·Armin Niklas FlinspachElisabeth Hannah Adam
Jul 24, 2020·Anesthesia and Analgesia·Azzeddine KermadAndreas Meiser
May 18, 2020·British Journal of Anaesthesia·Gertrude J Nieuwenhuijs-MoekeMichel M R F Struys

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
coronary artery bypass

Software Mentioned

AnaConDa

Related Concepts

Related Feeds