Survival after Metastasectomy for Metastatic Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Bladder Cancer
Vaibhav PatelGeorgios Gakis

Abstract

Background: Cisplatin-based combination chemotherapy is standard treatment for metastatic urothelial carcinoma; however, the vast majority of patients experience disease progression. As systemic therapy alone is rarely curative for the treatment of metastatic urothelial cancer, not only are new therapies needed but also refinement of general treatment principles. Herein, we conducted a systematic review and meta-analysis to explore the role of metastasectomy in metastatic urothelial carcinoma. Methods: We conducted a systematic review of the literature regarding local treatment for metastatic urothelial carcinoma. An online electronic search of the PubMed/MEDLINE and EMBASE databases was performed to identify peer-reviewed articles. All procedures were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Information was then extracted including number of patients, gender, the site of the primary urothelial tumor, site of metastasis, chemotherapy before or after metastasectomy, overall survival (OS), and disease specific survival (DSS) after metastasectomy. A meta-analysis was performed with those studies with sufficient survival data to obtain pooled overall survival...Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P M DoddD F Bajorin
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C N SternbergUNKNOWN European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group
Dec 11, 2003·The Journal of Urology·Arlene O Siefker-RadtkeRandall E Millikan
Mar 19, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Chul Jang KimYusaku Okada
Apr 17, 2010·Interactive Cardiovascular and Thoracic Surgery·Ryu KanzakiKen Kodama
Jun 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Joachim PfannschmidtHendrick Dienemann
Nov 26, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Emmanouil FokasRita Engenhart-Cabillic
Aug 2, 2011·The Annals of Thoracic Surgery·Haruhisa MatsugumaUNKNOWN Metastatic Lung Tumor Study Group of Japan
Aug 11, 2012·The Korean Journal of Thoracic and Cardiovascular Surgery·Woo Sik HanJoon Suk Park
Aug 12, 2015·Future Oncology·Srinath Sundararajan, Nicholas J Vogelzang
Aug 27, 2015·PloS One·Sumanta Kumar PalRebecca A Nelson
Feb 5, 2016·International Urology and Nephrology·Senol Tonyali, Sertac Yazici
Feb 18, 2017·The New England Journal of Medicine·Joaquim BellmuntUNKNOWN KEYNOTE-045 Investigators

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Citations

Feb 13, 2018·Expert Review of Anticancer Therapy·Michele MarchioniPierre I Karakiewicz
Jun 27, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Adam B WeinerRobert B Nadler
Jul 9, 2017·Annals of Surgical Oncology·Tohru NakagawaYukio Homma
Sep 30, 2020·International Journal of Surgery Case Reports·Mohamad MoussaNazih Bou Chahine
Apr 17, 2021·The Thoracic and Cardiovascular Surgeon·Selma OguzhanJoachim Schirren

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Methods Mentioned

BETA
dissection
surgical resection

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Cochrane Handbook
Review Manager ( RevMan )

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