PMID: 8606287Mar 1, 1996Paper

Survival after myocardial infarction in rats: captopril versus losartan

Journal of the American College of Cardiology
J J MilavetzS Goldman

Abstract

This study sought to compare the effects of angiotensin-converting enzyme inhibition versus angiotensin II receptor blockade on survival in rats with myocardial infarction. The effects of specific nonpeptide angiotensin receptor blocking agents on survival after myocardial infarction are unknown. Rats with a moderate to large myocardial infarction were treated with captopril (2 g/liter drinking water, n = 87) or losartan (2 g/liter drinking water, n = 96). Therapy was initiated immediately after coronary artery ligation and continued for 1 year. Uncensored median survival in captopril-treated rats that survived at least 48 h was 201.5 days versus 236.0 days for losartan-treated rats (p = 0.066). Median survival censored for rats with lung infections was 201.5 days in captopril-treated rats versus 243.0 days for losartan-treated rats (p = 0.028). Conscious hemodynamic measurements and remodeling data obtained at 1 year in the surviving rats (n = 5 for captopril; n = 9 for losarton) revealed no differences in heart weight, left ventricular pressure, dP/dt, cardiac index, time constant of relaxation or any variable of left ventricular remodeling. The only differences (mean +/- SD) were an increase in heart rate (293 +/- 19 vs. 266...Continue Reading

References

Jan 15, 1992·Biochemical and Biophysical Research Communications·R D FarhyA G Scicli
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn

❮ Previous
Next ❯

Citations

Aug 11, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Sophie GüntherJoachim Neumann
Aug 4, 1997·The American Journal of Cardiology·K C Wollert, H Drexler
Oct 9, 2001·Clinical Therapeutics·K Dickstein
Jun 27, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·P WhittakerR A Kloner
Jan 8, 2000·Fundamental & Clinical Pharmacology·M GervaisJ F Giudicelli
Jun 4, 1999·Journal of Clinical Pharmacology·M M McConnaugheyA J Ingenito
Jul 19, 2001·Japanese Journal of Pharmacology·D JinM Miyazaki
Feb 17, 1998·International Journal of Cardiology·M G NichollsA M Richards
May 19, 2004·Fundamental & Clinical Pharmacology·Colette LacourDino Nisato
Apr 1, 1997·The Journal of Laboratory and Clinical Medicine·C De Carvalho FrimmK T Weber
Aug 26, 2006·Journal of Pharmacological and Toxicological Methods·Kelly R PittsChristopher F Toombs
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J Ross, T Ryoke
Oct 8, 2011·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Jin-Sheng ZhangBao-Xia Zhang
Feb 18, 2003·Pharmacotherapy·J Herbert Patterson
Jul 5, 2005·Expert Opinion on Investigational Drugs·K DicksteinR Segal
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S Ørn, K Dickstein
Jul 6, 2005·Journal of Pharmacological Sciences·Takanori KusuyamaJunichi Yoshikawa
Sep 9, 2016·IEEE Transactions on Bio-medical Engineering·Kyle WeigandElizabeth Juneman
Mar 16, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yasuhiro MaejimaMitsuaki Isobe
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Lodewijk J WagenaarWiek H van Gilst
Nov 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ali PourdjabbarJean-Lucien Rouleau
May 10, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Randy T CowlingBarry H Greenberg
Feb 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·K KaurP K Singal
Mar 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Paul BridgmanRichard D Patten

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.