Survival after reconstructive surgery for hypoplastic left heart syndrome: A 15-year experience from a single institution

Circulation
W T MahleB J Clark

Abstract

There are limited data regarding the long-term survival of patients who have undergone reconstructive surgery for hypoplastic left heart syndrome (HLHS). We reviewed the 15-year experience at our institution to examine survival in the context of continued improvements in early operative results. Between 1984 and 1999, 840 patients underwent stage I surgery for HLHS. From review of medical records and direct patient contact, survival status was determined. The 1-, 2-, 5-, 10-, and 15-year survival for the entire cohort was 51%, 43%, 40%, 39%, and 39%, respectively. Late death occurred in 14 of the 291 patients discharged to home after the Fontan procedure, although only 1 patient has died beyond 5 years of age. Heart transplantation after stage I reconstruction was performed in 5 patients. Later era of stage I surgery was associated with significantly improved survival (P:<0.001). Three-year survival for patients undergoing stage I reconstruction from 1995 to 1998 was 66% versus 28% for those patients undergoing surgery from 1984 to 1988. Age >14 days at stage I and weight <2.5 kg at stage I were also associated with higher mortality (P:=0.004 and P:=0.01, respectively). Other variables, including anatomic subtype, heterotaxia, ...Continue Reading

References

Dec 24, 2005·Pediatric Cardiology·J M SimsicA M Atz
Nov 24, 2007·Pediatric Cardiology·B A JohnsonNancy S Ghanayem
Dec 15, 2007·Pediatric Cardiology·Carlo B PillaFernando A Lucchese
Jul 26, 2011·Pediatric Cardiology·Sarah GelehrterRobert Gajarski
Mar 23, 2013·Pediatric Cardiology·Jeffrey H Shuhaiber, Frank A Pigula
Mar 19, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Bradley S MarinoJudy A Shea
Dec 29, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Bradley S MarinoRichard Ittenbach
Sep 18, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Riad B M HoseinD J Barron
Mar 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Mark D RodefeldJohn W Brown
Feb 24, 2001·The Annals of Thoracic Surgery·W T MahleB J Clark
Jun 1, 2001·The Annals of Thoracic Surgery·A AzakieW G Williams
Jul 24, 2001·The Annals of Thoracic Surgery·W T MahleT L Spray
Jan 16, 2002·The Annals of Thoracic Surgery·B W DuncanF M Lupinetti
Jan 17, 2004·The Annals of Thoracic Surgery·Gail E WrightThomas J Kulik
Feb 5, 2004·The Annals of Thoracic Surgery·Paul A ChecchiaLeonard L Bailey
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Nancy S GhanayemJames S Tweddell
Oct 5, 2001·Journal of the American College of Cardiology·P C JenkinsA N Tosteson
Mar 6, 2004·Seminars in Neonatology : SN·Caren S Goldberg, Carlen A Gomez
Jan 2, 2010·Circulation. Cardiovascular Imaging·Anita SzwastJack Rychik
Nov 15, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Lamia Ait-AliPierluigi Festa
Jul 23, 2013·Journal of Cardiothoracic Surgery·Isabel PreeshagulK Stephen Suh
Jul 25, 2007·Annals of Cardiac Anaesthesia·Suresh Chengode, Priya R Menon
Jun 15, 2014·Journal of Cardiothoracic Surgery·Tara KaramlouGordon Cohen
Oct 1, 2013·The Journal of Thoracic and Cardiovascular Surgery·Melissa G Y LeeYves d'Udekem
Sep 9, 2006·Neuropsychology Review·M MiattonG Vingerhoets
Mar 29, 2014·The Journal of Thoracic and Cardiovascular Surgery·Nancy A RuddNancy S Ghanayem
Jun 14, 2013·Seminars in Fetal & Neonatal Medicine·Dietmar Schranz, Ina Michel-Behnke
Feb 8, 2007·Current Opinion in Cardiology·Brian L ReemtsenVaughn A Starnes
Jan 23, 2013·Current Opinion in Cardiology·David A Hehir, Nancy S Ghanayem
Apr 24, 2001·Current Opinion in Pediatrics·D B McElhinney, G Wernovsky
Jun 5, 2001·Current Opinion in Pediatrics·Peter C Laussen
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Susan R HintzELSO Registry
Feb 14, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Clifford L CuaPeter C Laussen
Jan 8, 2009·Interactive Cardiovascular and Thoracic Surgery·Takahiro TomoyasuNobuyuki Inoue
Jan 1, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Edythe B ThamNee S Khoo
Feb 8, 2014·The Journal of Thoracic and Cardiovascular Surgery·Jeremy L HerrmannChristopher E Mascio
Jul 16, 2013·The Journal of Thoracic and Cardiovascular Surgery·Pirouz ShamszadChristopher J Petit

Related Concepts

Incidence Studies
Hemi-Fontan Procedure
Cardiovascular Surgical Procedures
Hypoplastic Left Heart Syndrome
Heart Transplantation
Heterotaxy, Visceral,1, X-LINKED
Situs Ambiguus
Transplantation Aspects
Retrospective Studies
Survival Rate

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