Survival after recurrence in early-stage high-risk epithelial ovarian cancer: a Gynecologic Oncology Group study

Gynecologic Oncology
John K ChanJeffrey Bell

Abstract

This study aimed to evaluate the clinical outcome of recurrent early-stage high-risk epithelial ovarian cancer patients. Demographic and clinicopathological data were collected from women enrolled in GOG 157 who underwent surgical staging and had recurrent disease. Survival probability was estimated using Kaplan-Meier method, and hazard ratio of death was analyzed using Cox regression model. Of 74 women with recurrent early-stage high-risk ovarian cancer, the median age at recurrence was 63 years; 93% were White, 2.7% were Black, 2.7% were Asian, and 1.4% were Others. Fifty-eight percent had stage I, and the remainder had stage II disease. Clear cell, serous, endometrioid, mucinous, and other tumors consisted of 28.4%, 25.7%, 24.3%, 16.2%, and 5.4% of patients, respectively; in addition, 36.5% had ascites, 33.8% had positive cytology, and 43.2% had ruptured tumors. Fifty-eight percent underwent three cycles, and 42% had six cycles of adjuvant chemotherapy with paclitaxel and carboplatin. Recurrence was diagnosed clinically in 46% and radiographically in 54% of women. The median time from completion of primary chemotherapy to recurrence (treatment-free interval, TFI) was 21 months. Overall, median survival after recurrence was 2...Continue Reading

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Citations

Jul 28, 2013·International Journal of Clinical Oncology·Yui TomitaKumi Shimamoto
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Aug 26, 2020·Pathology, Research and Practice·Akiko YamamotoMasanobu Kitagawa
Jan 7, 2022·Obstetrics and Gynecology·John K ChanJeffrey G Bell

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