Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999

Cancer
Carlos Rodriguez-GalindoA S Pappo

Abstract

Despite improved therapies, 30-40% of patients with Ewing tumors (ET) experience recurrence and have a poor prognosis. The authors analyzed factors prognostic of survival in patients with recurrent ET. The authors assessed the relation between postrecurrence survival (PRS) and demographic, disease, and treatment factors in 71 patients who experienced recurrent ET after treatment on one of three consecutive institutional protocols. Thirty-four patients (47.9%) had distant recurrence, 25 patients (35.2%) had local recurrence, and 12 patients (16.9%) had both distant and local recurrence at a median of 1.7 years after diagnosis. The probability of 5-year PRS (+/- 1 standard error) was 17.7%+/-4.5%. Recurrence > or = 2 years after diagnosis predicted a significantly better outcome (5-year PRS, 34.9%+/-8.5%) compared with earlier recurrence (5.0%+/-2.8%; P < 0.001). Patients who had both local and distant recurrence fared worse (5-year PRS, 12.5%+/-8.3%) compared with patients who had local recurrence alone (21.7%+/-7.8%) or distant recurrence alone (17.6+/-6.1%). Among patients with local recurrence alone, those who underwent salvage with radical surgery had significantly higher 5-year PRS estimates (31.4%+/-11.6%) compared with th...Continue Reading

References

Nov 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W H MeyerC B Pratt
Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·Y AraiB N Rao
Jul 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R G EvansF B Askin
Sep 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E O BurgertP Thomas
Oct 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M E NesbitJ M Kissane
Nov 1, 1990·International Journal of Radiation Oncology, Biology, Physics·E BarbieriL Babini
Feb 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A HayesL Magill
Jan 1, 1987·Medical and Pediatric Oncology·F A HayesH O Hustu
Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H KushnerG Heller
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S BurdachE Koscielniak
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A W CraftD Pearson
Apr 17, 1998·Medical and Pediatric Oncology·T KlingebielJ Treuner
May 29, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PaulussenH Jürgens
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M PaulussenH Jürgens
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·S S DonaldsonJ J Shuster
Nov 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A CraftI Lewis
Mar 26, 1999·Cancer·C HoffmannH Jürgens
Jul 9, 1999·Medical and Pediatric Oncology·T E MerchantJ H Healey
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N M MarinaW H Meyer
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G BacciP Picci
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A G ShankarA W Craft

❮ Previous
Next ❯

Citations

Apr 6, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Punit SharmaRakesh Kumar
Sep 8, 2007·Cancer Chemotherapy and Pharmacology·Sebastian WernerUdo Kontny
May 22, 2013·Current Oncology Reports·Nino RainussoJason T Yustein
Jun 9, 2005·Hematology/oncology Clinics of North America·Richard Carvajal, Paul Meyers
Feb 5, 2008·Bone Marrow Transplantation·S L GardnerM Eapen
Oct 19, 2010·Sarcoma·Patrick P LinGuillermina Lozano
Mar 19, 2013·Cancer Cell International·Keiichiro IidaYukihide Iwamoto
Oct 4, 2008·Annals of the Royal College of Surgeons of England·S A HannaT W R Briggs
Jan 29, 2014·Cancer Chemotherapy and Pharmacology·Atif A AhmedLars Wagner
Mar 26, 2011·Sarcoma·Mona S JahromiJoshua D Schiffman
Mar 5, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mark A ApplebaumSteven G DuBois
Mar 8, 2013·American Journal of Clinical Oncology·Steven I RobinsonNadia N Laack
May 16, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mark D MurpheyMark J Kransdorf
Jan 25, 2003·Current Opinion in Pediatrics·John G KennedyBang H Hoang
Apr 26, 2011·Acta neurochirurgica·Pravin Shashikant SalunkeJohn D Pfeifer
Apr 10, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J L López GuerraM J Ortiz
Sep 9, 2008·Journal of Pediatric Hematology/oncology·Steven G DuBoisHolcombe E Grier
Sep 4, 2009·Journal of Pediatric Hematology/oncology·Jaume MoraCarmen de Torres
Jul 25, 2015·International Journal of Molecular Sciences·Lorna C KellyMaureen J O'Sullivan
Feb 24, 2011·Expert Review of Anticancer Therapy·Joseph Rosenthal, Anna B Pawlowska
Apr 12, 2008·Expert Review of Anticancer Therapy·Patrick J Leavey, Anderson B Collier
Feb 25, 2009·Expert Opinion on Investigational Drugs·Rachael WindsorJeremy Whelan
Aug 8, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A RaciborskaM Dziuk
Jul 22, 2004·Pediatric Blood & Cancer·Jeremy S WhelanUNKNOWN London Bone and Soft Tissue Tumour Service
Mar 29, 2011·Pediatric Blood & Cancer·Martin StahlUta Dirksen
Jun 19, 2013·Pediatric Blood & Cancer·Anna RaciborskaWojciech Wozniak
Apr 15, 2014·Pediatric Blood & Cancer·Meybrit RasperUta Dirksen
Jul 29, 2009·Pediatric Blood & Cancer·Denise A CaseyPaul A Meyers
Apr 20, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G BacciP Picci
Jan 15, 2015·Pediatric Blood & Cancer·Stefano FerrariAdalberto Brach del Prever
Oct 16, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David R ShookWing Leung
May 28, 2004·Expert Opinion on Pharmacotherapy·Carlos Rodriguez-Galindo

❮ Previous
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