PMID: 9529033Apr 7, 1998Paper

Survival after relapse in childhood acute lymphoblastic leukemia: impact of site and time to first relapse--the Children's Cancer Group Experience

Cancer
P S GaynonM E Trigg

Abstract

Childhood acute lymphoblastic leukemia is the single most common childhood malignancy. Despite substantial improvements in therapy, cases in which relapse occurs are still more common than newly diagnosed cases of many other childhood cancers. The survival of patients who relapse despite improved therapy continues to be of interest. One thousand one hundred forty-four relapses and 28 second malignant neoplasms were identified among the 3712 eligible patients enrolled on Children's Cancer Group trials between 1983 and 1989. The details of treatment after relapse were not accessible. Subsequent secondary event free survival and overall survival were examined by the site of and time to initial relapse. A variety of potential prognostic factors were examined employing the log rank statistic and Wilcoxon regression model. Rates of 6-year survival (+/- standard error) after isolated bone marrow, isolated central nervous system (CNS), and isolated testis relapse were 20%+/-2%, 48%+/-4%, and 70%+/-5%, respectively. Rates of survival after isolated bone marrow relapse at 0-17 months, 18-35 months, and after 36 months were 6%+/-2%, 11%+/-2%, and 43%+/-4%, respectively. Rates of survival after isolated CNS relapse at 0-17 months, 18-35 mo...Continue Reading

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Citations

Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P S GaynonH N Sather
Oct 10, 2003·Oncogene·Seisho TakeuchiH Phillip Koeffler
Nov 18, 2003·British Journal of Haematology·Judith M ChessellsIan M Hann
Feb 11, 2005·Journal of Pediatric Hematology/oncology·Jean-Hugues DalleMartin A Champagne
Feb 12, 2005·Pediatric Blood & Cancer·C M Zwaan, A J P Veerman
Nov 13, 2007·Pediatric Radiology·J Herman KanSusan A Connolly
Nov 15, 2007·Pediatric Blood & Cancer·Kelly M JackmanStephen P Hunger
Oct 22, 2008·Current Oncology Reports·Robert J Wells
Aug 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A RaetzUNKNOWN Children's Oncology Group Pilot Study
Jan 6, 2010·Journal of Pediatric Hematology/oncology·Aliva De, Jill S Menell
Jun 5, 2012·PloS One·Stefan EssigUNKNOWN Swiss Pediatric Oncology Group (SPOG)
Aug 8, 2013·JAAPA : Official Journal of the American Academy of Physician Assistants·Kayla ZappoloJean Covino
Apr 19, 2013·British Journal of Haematology·Franziska MeyrJohann Hitzler
Apr 30, 2013·Indian Journal of Pediatrics·Sandeep Jain, Gauri Kapoor
Aug 30, 2014·Journal of Pediatric Hematology/oncology·Richa JainRam K Marwaha
Apr 3, 2019·The Oncologist·Henry T QuachDouglas B Johnson
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Mar 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elly BarryLewis B Silverman

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