Survival algorithms and outcome analysis in primary biliary cirrhosis

Seminars in Liver Disease
T M Pasha, E R Dickson

Abstract

The natural history of primary biliary cirrhosis (PBC) is one of slowly progressive cholestasis with liver damage, development of cirrhosis with its concomitant complications, and death unless the patient undergoes liver transplantation. Natural history studies have identified several variables associated with a decreased survival in patients with PBC. The course of the disease can be divided into three time periods: (1) a presymptomatic phase, probably lasting up to 20 years; (2) a symptomatic phase, with anicteric or mild jaundice, lasting up to 5 to 10 years; and (3) a preterminal or accelerated phase with marked jaundice, lasting up to 2 years. Since the course of the disease is one of slow progression leading to liver failure and death unless liver transplantation intervenes, several investigators have developed statistical models to predict survival. The ability to predict survival for individual patients with PBC has been valuable in the management of these patients, particularly in patient selection and timing of liver transplantation. In addition, survival estimates can be utilized in education and counseling patients and their families. These models may also be used to evaluate the efficacy of new treatments by compar...Continue Reading

Citations

Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R L Carithers
May 6, 2008·Clinics in Liver Disease·Marlyn J Mayo
May 10, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karen F MurrayUNKNOWN AASLD
May 18, 2004·The American Journal of Medicine·Jayant A Talwalkar, Patrick S Kamath
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Wei Xin LiAi Ping Zhang
Mar 24, 2017·Current Opinion in Gastroenterology·Jeremy I Sullivan, Don C Rockey

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