Survival Analysis and Interpretation of Time-to-Event Data: The Tortoise and the Hare

Anesthesia and Analgesia
Patrick Schober, Thomas R Vetter

Abstract

Survival analysis, or more generally, time-to-event analysis, refers to a set of methods for analyzing the length of time until the occurrence of a well-defined end point of interest. A unique feature of survival data is that typically not all patients experience the event (eg, death) by the end of the observation period, so the actual survival times for some patients are unknown. This phenomenon, referred to as censoring, must be accounted for in the analysis to allow for valid inferences. Moreover, survival times are usually skewed, limiting the usefulness of analysis methods that assume a normal data distribution. As part of the ongoing series in Anesthesia & Analgesia, this tutorial reviews statistical methods for the appropriate analysis of time-to-event data, including nonparametric and semiparametric methods-specifically the Kaplan-Meier estimator, log-rank test, and Cox proportional hazards model. These methods are by far the most commonly used techniques for such data in medical literature. Illustrative examples from studies published in Anesthesia & Analgesia demonstrate how these techniques are used in practice. Full parametric models and models to deal with special circumstances, such as recurrent events models, com...Continue Reading

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Jun 16, 2018·Anesthesia and Analgesia·Patrick Schober, Thomas R Vetter

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Citations

Dec 12, 2018·Anesthesia and Analgesia·Thomas R Vetter, Douglas Morrice
May 10, 2020·Anesthesia and Analgesia·Patrick Schober, Thomas R Vetter
Sep 23, 2020·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Sebastiaan M BossersUNKNOWN BRAIN-PROTECT Collaborators
Sep 15, 2020·Anesthesia and Analgesia·Patrick Schober, Thomas R Vetter
Feb 19, 2020·Anesthesia and Analgesia·Patrick Schober, Thomas R Vetter
Oct 21, 2020·Anesthesia and Analgesia·Patrick Schober, Thomas R Vetter
Dec 8, 2020·JAMA Neurology·Sebastiaan M BossersUNKNOWN BRAIN-PROTECT collaborators
Mar 2, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Salil Vasudeo DeoVarun Sundaram
Mar 17, 2021·Anesthesia and Analgesia·Patrick Schober, Thomas R Vetter
May 30, 2021·Postgraduate Medical Journal·Charles CoughlanCéire E Costelloe
Aug 17, 2021·The American Journal of Sports Medicine·Michael PerretGregory Hoy
Nov 3, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kirati KengklaSurasak Saokaew
Jan 11, 2022·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sushmita RaiUday C Ghoshal

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