PMID: 22575139May 12, 2012Paper

Survival analysis on AIDS antiretroviral therapy in Henan province during 2003-2009

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Ding-yong SunZhe Wang

Abstract

To study the effect of a government-provided-free highly active antiretroviral treatment (HAART) program, on the reduction of mortality and relevant risk factors among adult (AIDS) patients in Henan province. Data on the survival and deaths of AIDS patients were collected from the National HAART reporting system between 2003 and 2009. Cox proportional hazards model was applied to analyze those factors that affecting the survival time of the patients. 24 669 cases were enrolled to this study in Henan province, from 2003 to 2009. The overall mortality declined from 20.1/100 person-years in 2003 to 5.1/100 person-years in 2009. There was significant difference between the survival curves of different CD4(+)T counts and different numbers of opportunistic infection syndromes. Results from the Multivariate Cox proportional hazards regression analysis indicated that CD4(+) T cell counts (> 200 cells/µl, 50 - 199 cells/µl) was a risk factor to death, with hazard ratio as 4.4 and 2.0 respectively. Hb of the patients that lower than 90, was a risk factor to death with the HR = 1.8. Number of opportunistic infection (OIs) episodes was a risk factor to the mortality (HR = 1.7). In addition, other risk factors would include age (≥ 60 years,...Continue Reading

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