Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country

Pediatric Cardiology
Mohd Nizam Mat BahNorazah Zahari

Abstract

Critical congenital heart disease (CCHD) is associated with significant morbidity and mortality. However, data on survival of CCHD and the risk factors associated with its mortality are limited. This study examined CCHD survival and the risk factors for CCHD mortality. Using a retrospective cohort study of infants born with CCHD from 2006 to 2015, survival over 10 years was estimated using Kaplan-Meier analysis, and the risk factors for mortality were analyzed using multivariate Cox proportional hazards regression. A total of 491 CCHD cases were included in the study, with an overall mortality rate of 34.8% (95% confidence interval [CI] 30.6-39.2). The intervention/surgical mortality rate was 9.8% ≤ 30 days and 11.5% > 30 days after surgery, and 17% died before surgery or intervention. The median age at death was 2.7 months [first quartile: 1 month, third quartile: 7.3 months]. The CCHD survival rate was 90.4% (95% CI 89-91.8%) at 1 month, 69.3% (95% CI 67.2-71.4%) at 1 year, 63.4% (95% CI 61.1-65.7%) at 5 years, and 61.4% (95% CI 58.9-63.9%) at 10 years. Weight of < 2 kg at diagnosis, associated syndromes, poor pre-operative condition, and non-duct-dependent CCHD were independent risk factors for poor survival, with hazard rat...Continue Reading

References

Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Nov 22, 2005·Cardiology in the Young·Robert M FreedomRobert H Anderson
Jun 9, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·C WrenK Khawaja
Oct 30, 2007·Circulation·Luis A LarrazabalAldo R Castañeda
Oct 8, 2008·Archives of Pediatrics & Adolescent Medicine·Ruey-Kang R ChangSandra Rodriguez
Sep 25, 2010·Journal of the American College of Cardiology·Paul KhairyAriane J Marelli
Apr 18, 2013·Pediatrics and Neonatology·Shu-Jen YehMei-Hwan Wu
Apr 24, 2013·Pediatrics·Matthew E OsterAdolfo Correa
Nov 13, 2013·Cardiovascular Journal of Africa·Julien Ie Hoffman
Jul 2, 2014·Pediatrics·David E FixlerMark A Canfield
Sep 11, 2014·PloS One·Rachel L KnowlesUNKNOWN UKCSCHD (UK Collaborative Study of Congenital Heart Defects) collaborators
Apr 24, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B J HollandC R Woods
Jul 2, 2015·Archives of Disease in Childhood·Luke EckersleyThomas L Gentles
Mar 5, 2016·PloS One·José Luis Torres-CosmeTeresa Murguía-Peniche
Jun 18, 2016·Journal of the American Heart Association·Kate E Best, Judith Rankin

❮ Previous
Next ❯

Citations

Sep 9, 2019·Journal of Perinatal Medicine·Alaa EbrashyMohamed Momtaz
Jun 22, 2019·European Journal of Pediatrics·Norazah ZahariMeow-Keong Thong
Jun 27, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mohd Nizam Mat BahEmieliyuza Yusnita Alias
Dec 15, 2020·Annals of Pediatric Cardiology·Mohd Nizam Mat BahEmieliyuza Yusnita Alias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.