Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats.

PloS One
Ismayil AhmetMark Talan

Abstract

Despite remarkable progress in treatment of chronic heart failure (CHF) over the last two decades, mortality, personal suffering and cost remain staggering, and effective interventions are still a challenge. Previously we reported that a blueberry-enriched diet (BD) attenuated necroapoptosis and inflammation in periinfarct area in a rat model of myocardial infarction (MI). To test the hypothesis that BD will attenuate the course of CHF, including mortality and cardiac remodeling during the first year after induction of MI in rats. Two weeks after coronary artery ligation, rats were divided into two groups of similar average MI size, measured by echocardiography, and then 12-mo dietary regimens were initiated as follows: ad libitum regular diet (control, CD, n = 27) and isocaloric food with 2% blueberry supplement (BD, n = 27) also available ad libitum. These dietary groups were compared to each other and to sham group (SH). Mortality over the 12 mo was reduced by 22% in BD compared with CD (p<0.01). In the course of developing CHF, BD had no effect on the body weight, heart rate or blood pressure. Bi-monthly Echo revealed significant attenuation of the LV chamber remodeling, LV posterior wall thinning, and MI expansion in BD co...Continue Reading

References

Jun 1, 1982·Circulation·J S Hochman, B H Bulkley
Oct 26, 1999·Circulation Research·S GuerraP Anversa
May 30, 2002·European Journal of Heart Failure·Simon StewartJohn J J V McMurray
May 17, 2003·The Journal of Clinical Investigation·Detlef WenckerRichard N Kitsis
Mar 15, 2005·The Journal of Clinical Investigation·Roger S-Y FooRichard N Kitsis
May 5, 2005·Neurobiology of Aging·Rachel L GalliJames A Joseph
Jun 1, 2005·Lancet·John J V McMurray, Marc A Pfeffer
Jan 13, 2006·Circulation·Thomas ThomUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 28, 2006·Journal of Cardiac Failure· Heart Failure Society Of America
Feb 28, 2006·Journal of Cardiac Failure·UNKNOWN Heart Failure Society Of America
Mar 16, 2007·The New England Journal of Medicine·Stefan Neubauer
Dec 19, 2007·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 25, 2008·Heart Failure Reviews·Richard N Kitsis, Jagat Narula
Jul 26, 2008·Archives of Gerontology and Geriatrics·G CaoB P Yu
Dec 17, 2008·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jun 19, 2009·PloS One·Ismayil AhmetMark Talan

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Citations

Oct 3, 2013·Journal of Agricultural and Food Chemistry·Ana Rodriguez-MateosJeremy P E Spencer
Sep 26, 2013·Journal of Agricultural and Food Chemistry·Ana Rodriguez-MateosAlan Crozier
Mar 30, 2013·Canadian Journal of Physiology and Pharmacology·Sandhya KhuranaT C Tai
Aug 27, 2011·Journal of Agricultural and Food Chemistry·Chenghui XieXianli Wu
Sep 24, 2015·Journal of Cardiovascular Translational Research·William J Richardson, Jeffrey W Holmes
Mar 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yasmin E LoperaSusana Mosca
Dec 10, 2013·Acta Physiologica Hungarica·M MahmoudabadyK McEntee
Jul 13, 2012·American Journal of Hypertension·Sijo J ThandapillyHope D Anderson
Aug 1, 2019·Canadian Journal of Physiology and Pharmacology·Yue SunNeelam Khaper
Aug 28, 2020·Molecular Nutrition & Food Research·Paulina Bryl-GóreckaDavid Erlinge
Aug 11, 2018·Journal of Agricultural and Food Chemistry·Xianli WuPamela R Pehrsson

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