PMID: 6967462May 1, 1980Paper

Survival and kinetic response of V79-spheroids after exposure to heavy ion beams

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
C Lücke-HuhleC A Tobias

Abstract

Multicellular V79-spheroids and V79-monolayer cultures were irradiated with charged particle beams. The beams studied and their initial extraction energies were carbon (400 MeV/amu), neon (425 MeV/amu) and argon (570 MeV/amu). Survival was measured at a position in the plateau, and at a position in the middle of a 4 cm extended Bragg peak. Relative biological efficiency (r.b.e.) values for survival of spheroid cells at peak positions were high (4.1--4.2) in comparison to those obtained with monolayer cultures (1.8--2.4) of the same cell line. This finding is explained by the fact that three dimensional cell contact, which benefits survival after low LET radiation, does not influence survival after heavy ion irradiations in the Bragg peak. The peak-plateau r.b.e.-ratio was most advantageous for the carbon-ion beam (= 4.2). Whereas non-cycling inner spheroid cells showed hardly any kinetic changes up to 24 hours after heavy ion irradiation, outer cycling spheroid cells were arrested in G2 + M within a few hours after exposure.

References

Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·J R Castro, J M Quivey
Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·S B Curtis
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S P Hawkes, J C Bartholomew
Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·J D ChapmanR C Urtasun
Jan 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C Lücke-Huhle, H Dertinger
Jun 1, 1977·The British Journal of Radiology·R E Durand, P L Olive
Sep 1, 1973·The Review of Scientific Instruments·J A SteinkampP F Mullancy

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Citations

Feb 1, 2013·International Journal of Radiation Biology·Yoshihiro FujiiTakamitsu A Kato
Feb 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Herman SuitAlexei Trofimov
Aug 9, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Claere von NeubeckMarianne B Sowa
Mar 2, 2019·International Journal of Radiation Biology·Carmel Mothersill, Colin Seymour

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