Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children's Cancer Group

Journal of Neurosurgery
P L RobertsonJ Wisoff

Abstract

Ependymomas in children continue to generate controversy regarding their histological diagnosis and grading. optimal management, and possible prognostic factors. To increase our knowledge of these tumors the authors addressed these issues in a cohort of children with prospectively staged ependymomas treated with radiotherapy and chemotherapy. Children between the ages of 2 and 17.3 years harboring an intracranial ependymoma confirmed by a central review of the tumor's pathological characteristics were treated according to Children's Cancer Group Protocol 921 from 1986 to 1992. Treatment following surgery and postoperative tumor staging (including brain computerized tomography or magnetic resonance [MR] imaging, spinal MR imaging or myelography, and cerebrospinal fluid cytological investigation) included craniospinal irradiation with a local boost to the primary tumor and patient randomization to receive adjuvant chemotherapy with either 1) CCNU, vincristine, and prednisone, or 2) the eight-drugs-in-1-day regimen. Centralized review of the tumor pathological characteristics revealed 20 ependymomas and 12 anaplastic ependymomas in the 32 children included in the study. Diagnoses made at the individual institutions included anapla...Continue Reading

References

Jan 1, 1977·Child's Brain·R A Coulon, K Till
Sep 1, 1977·Radiology·Y H Kim, J V Fayos
Aug 1, 1977·Cancer·S J Mork, A C Loken
Sep 1, 1976·Journal of Neurosurgery·G J DohrmannJ T Flannery
Jun 1, 1975·Radiology·Y OnoyamaT Sakamoto
Nov 11, 1975·Archives of Neurology·R M ShumanR W Leech
Jul 1, 1992·Journal of Neuro-oncology·J K ChiuR Shallenberger
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L J VanuytselM Brada
Aug 1, 1991·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D SchifferA Tribolo
Jan 1, 1991·Acta neurochirurgica·R I ErnestusR Schröder
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·J W GoldweinG J D'Angio
Mar 1, 1990·Journal of Neurosurgery·G B NazarE B Hendrick
Jan 1, 1989·Journal of Neurosurgery·G W Ross, L J Rubinstein
Aug 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T W PendergrassW A Bleyer
Oct 1, 1987·International Journal of Radiation Oncology, Biology, Physics·E G ShawJ D Earle
Oct 1, 1970·Journal of Neurosurgery·B M Barone, A R Elvidge
Jul 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H J Bloom
Jan 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J E Marks, S J Adler
Jul 1, 1995·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D P JayawickremeW F Harkness
Jul 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H CohenP Stanley
Jun 1, 1994·The Australian & New Zealand Journal of Obstetrics & Gynaecology·H G Burger
Aug 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R GeyerJ L Finlay
Jan 15, 1994·International Journal of Radiation Oncology, Biology, Physics·P RousseauA Rey
Feb 1, 1993·Journal of Neuro-oncology·J J KovalicK A Roth
Jan 1, 1952·Journal of Neurosurgery·O T BAILEYA F SUSEN
May 1, 1952·Journal of Neurosurgery·E A BERING
Oct 1, 1949·Journal of Neuropathology and Experimental Neurology·N RINGERTZ, A REYMOND

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Citations

Sep 5, 2002·Cancer·Marc C Chamberlain
Feb 2, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Paul KremerC R Wirtz
Nov 1, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Martin BeneschChristian Urban
Jan 21, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andrew S LittleCharles Teo
Feb 13, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Karen D Wright, Amar Gajjar
Apr 10, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mark D Krieger, J Gordon McComb
Apr 10, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Aabir ChakrabortyKim Phipps
Apr 11, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Wesley HsuGeorge I Jallo
Jun 2, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Robert A SanfordFrederick A Boop
Apr 18, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Thomas E Merchant
May 22, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kyu-Won ShimJoong-Uhn Choi
Jun 2, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·M SangraC Mallucci
Jun 26, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Constantinos CharalambidesSpyros Sgouros
Jul 25, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Frederick A Boop, Spyros Sgouros
Feb 11, 2012·Acta Neuropathologica·Khalida WaniUNKNOWN Collaborative Ependymoma Research Network
Oct 1, 2005·Journal of Neuro-oncology·Thomas E Merchant, Maryam Fouladi
Jun 12, 2002·Current Treatment Options in Oncology·K J CohenJ Glod
Oct 31, 2003·Current Treatment Options in Oncology·Timothy J Moynihan
Jul 17, 2012·Current Treatment Options in Oncology·Karen D Wright, Amar Gajjar
Apr 15, 2003·Current Neurology and Neuroscience Reports·Marc C Chamberlain
Sep 1, 2006·Current Treatment Options in Neurology·Sajeel ChowdharyMarc Chamberlain
Mar 21, 2009·Pathology Oncology Research : POR·Klara KuncovaJosef Zamecnik
Sep 4, 2009·Pathology Oncology Research : POR·Dusan VitanovicsDénes Afra
Jun 16, 2005·Current Problems in Pediatric and Adolescent Health Care·Adam S Levy
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sabine Mueller, Susan Chang
Sep 1, 2000·Journal of the Neurological Sciences·A KorshunovV Timirgaz
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Thomas E MerchantLarry E Kun
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·A C Paulino, B C Wen
Sep 23, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M LewandowiczJ L Darling
Aug 1, 2000·Clinical Privilege White Paper
Jul 27, 2011·Nature Reviews. Neurology·Ian F Pollack, Regina I Jakacki
Jun 30, 2004·The American Journal of Surgical Pathology·Stefan WolfsbergerJohannes Hainfellner
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sarah E GibsonRichard A Prayson
Jun 2, 2011·Journal of Negative Results in Biomedicine·David W EllisonRichard G Grundy
Aug 15, 2008·Neuro-oncology·Lee RidleyUNKNOWN Children's Cancer and Leukaemia Group Biological Studies Committee
Aug 5, 2003·Paediatric Drugs·Jacques GrillKalifa Chantal
Mar 17, 2009·Future Oncology·Maura MassiminoFelice Giangaspero
Jul 11, 2006·The Keio Journal of Medicine·Yuichi Hirose, Kazunari Yoshida
Feb 3, 2011·Journal of Neurosurgery. Pediatrics·Jonathan A ForbesMatthew M Pearson
Sep 3, 2011·Journal of Neurosurgery. Pediatrics·Maura MassiminoLorenza Gandola

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Methods Mentioned

BETA
surgical
biopsy
bone marrow aspiration
surgical resection
total resection
imaging techniques

Software Mentioned

Statexact
Cytel

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