Survival and prognostic factors for childhood malignant liver tumors: analysis of harmonized clinical data.

Cancer Epidemiology
Maria A KaralexiMoscow childhood liver tumor study group

Abstract

Despite overall striking advances in survival of childhood liver tumors, outcomes remain poor for specific patient segments. We aimed to assess overall survival (OS) of this rare disease and evaluate the generalizability of prognostic variables included in international collaborative systems using, for the first time, harmonized clinical data from two geographically different cohorts (Greece and Moscow). Data for children (0-14 years) with liver tumors were retrieved from two Southern-Eastern European areas (Greece; 2001-2019 and Moscow; 2012-2019). Kaplan-Meier curves were constructed, and OS values were derived from Cox proportional models controlling for study variables. A total of 171 newly diagnosed cases (54.4% males) were included. The OS5-year exceeded 80% in patients <5 years, reaching 85% among 133 patients with hepatoblastoma (HBL). By contrast, children with other than HBL histology, especially hepatocellular carcinoma (HCC) had significantly worse prognosis (hazard ratio [HR] HCC: 7.09, 95% confidence intervals [CI]: 2.56-19.65; HR other liver tumors: 5.18; 95%CI: 2.15-12.49). The OS5-year was poorer (40%-60%) in patients with extensive local, metastatic or relapsed disease. By contrast, a significantly lower risk ...Continue Reading

References

Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P CzaudernaUNKNOWN Liver Tumors Study Group of the International Society of Pediatric Oncology
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anil DarbariKathleen B Schwarz
Dec 23, 2006·Pediatric Radiology·Derek J RoebuckUNKNOWN International Childrhood Liver Tumor Strategy Group
Jan 2, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maretta De IorisGiorgio Perilongo
Jul 23, 2008·The Oncologist·Jason B Litten, Gail E Tomlinson
Nov 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Milton J FinegoldChristine Ann O'Mahony
Mar 25, 2009·Pediatric Surgery International·John D HortonDonald E Meier
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·József ZsírosGiorgio Perilongo
Mar 4, 2011·Pediatric Blood & Cancer·Kyung Nam KohJong Jin Seo
Jun 22, 2011·Clinics in Liver Disease·Nedim Hadzic, Milton J Finegold
Jul 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marcio H MalogolowkinMilton J Finegold
Jun 9, 2012·Pediatric Blood & Cancer·Giorgio PerilongoJames Feusner
Jun 14, 2012·Pediatric Blood & Cancer·Logan G Spector, Jill Birch
Apr 23, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Bassan J AllanJuan E Sola
Sep 7, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dolores López-TerradaMilton J Finegold
Dec 11, 2013·Current Opinion in Pediatrics·Piotr CzaudernaRebecka L Meyers
Jul 11, 2014·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Brigitte LacourJacqueline Clavel
Aug 12, 2014·World Journal of Gastroenterology : WJG·Dolores Ayllon TeranJavier Briceño Delgado
Dec 15, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Piotr CzaudernaRebecka Meyers
Sep 30, 2018·Clinics in Liver Disease·Kenneth Ng, Douglas B Mogul
Oct 18, 2019·Pediatric Radiology·Govind B ChavhanAbha A Gupta
Oct 28, 2019·Cancer Communications·Jincheng FengKatrin Hoffmann
Dec 7, 2019·Annals of Translational Medicine·Tie-Cheng FengZhi-Ming Wang

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