Survival and prognostic variables of cutaneous melanoma observed between 1995 and 2000 at Istituto Dermopatico Dell'Immacolata (IDI-IRCCS), Rome, Italy

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Cristina FortesPaolo Pasquini

Abstract

Melanoma is an increasingly common malignancy of melanocytes, with incidence rates steadily rising over the past several decades. The objective of this study was to evaluate 5-year survival and to investigate the association between melanoma mortality and clinical and histological features. We conducted a 5-year cohort study among 1020 patients from the same geographic area (Rome) with a single primary cutaneous melanoma diagnosed between January 1995 and December 2000. Survival probability was determined by Kaplan-Meier estimates, and prognostic factors were evaluated by multivariate analysis (Cox proportional hazards model). Survival decreased with increasing age (P for trend <0.049) and Breslow thickness (P for trend <0.0001). In the multivariate Cox model, Breslow thickness was the only independent prognostic factor for mortality in primary melanoma patients. The risk of death among patients with melanoma increased with increasing tumour thickness 0.76-1.49 mm (relative risk (RR) 2.67, 95% confidence interval (95% CI) 0.63-11.4); 1.50-4.0 mm (RR 6.38, 95% CI 1.75-23.2), >4.0 mm (RR 34.6, 95% CI 8.23-145.7) (P for trend <0.0001). The Years of Life Lost (YLLs) for the Breslow categories < or =0.75 mm, 0.76-1.49 mm, 1.50-4.0 m...Continue Reading

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Citations

Jun 7, 2013·Anais Brasileiros De Dermatologia·Lucio BakosCristina Fortes
Sep 16, 2006·Journal of Cancer Research and Clinical Oncology·Denitsa KoynovaNelleke Gruis
Jun 4, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Cristina FortesFranco Melchi
May 2, 2015·Melanoma Research·Cristina FortesPaola Michelozzi
Nov 3, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E de VriesJ-W W Coebergh

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