Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis

Lancet
J A GreenC J Williams

Abstract

The US National Cancer Institute alert in February, 1999, stated that concomitant chemotherapy and radiotherapy should be considered for all patients with cervical cancer. Our aim was to review the effects of chemoradiotherapy on overall and progression-free survival, local and distant control, and acute and late toxicity in patients with cervical cancer. With the methodology of the Cochrane Collaboration, we did a systematic review of all known randomised controlled trials done between 1981 and 2000 (17 published, two unpublished) of chemoradiation for cervical cancer. The trials included 4580 randomised patients, and 2865-3611 patients (62-78%) were available for analysis. Cisplatin was the most common agent used. The findings suggest that chemoradiation improves overall survival (hazard ratio 0.71, p<0.0001), whether platinum was used (0.70, p<0.0001) or not (0.81, p=0.20). A greater beneficial effect was seen in trials that included a high proportion of stage I and II patients (p=0.009). An improvement in progression-free survival was also seen with chemoradiation (0.61, p<0.0001). Thus, the absolute benefit in progression-free and overall survival was 16% (95% CI 13-19) and 12% (8-16), respectively. A significant benefit o...Continue Reading

References

Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Apr 1, 1987·International Journal of Radiation Oncology, Biology, Physics·K E Wallner, G C Li
Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
Nov 12, 1994·BMJ : British Medical Journal·K DickersinC Lefebvre
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Apr 15, 1999·The New England Journal of Medicine·G M Thomas
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F TierneyM K Parmar
Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·P PisaniJ Ferlay
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts

❮ Previous
Next ❯

Citations

May 24, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Arne GruenSimone Marnitz
Oct 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Tzu-Chen YenKoon-Kwan Ng
Oct 21, 2010·World Journal of Urology·Sean P Elliott, Bahaa S Malaeb
Mar 10, 2006·Archives of Gynecology and Obstetrics·P SangheraJ Simon
Feb 17, 2010·Archives of Gynecology and Obstetrics·Na WangTian-Gen Ni
Mar 29, 2011·Archives of Gynecology and Obstetrics·Ana Francisca VazAarão Mendes Pinto-Neto
Dec 17, 2011·Archives of Gynecology and Obstetrics·Jong Ha HwangJoo-Young Kim
Jan 3, 2012·Archives of Gynecology and Obstetrics·Uwe GüthMary McCormack
Nov 15, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·C C HensonH J N Andreyev
Dec 15, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vanessa Fuchs-TarlovskyGuillermo Manuel Ceballos-Reyes
Mar 21, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Caroline C HensonJohn McLaughlin
Jul 24, 2008·Journal of Cancer Survivorship : Research and Practice·Sophie D FossåAlv A Dahl
Jan 16, 2008·Current Treatment Options in Oncology·Shay Ashouri, Agustin A Garcia
Oct 16, 2004·Current Oncology Reports·Juan E SardiJuan J Sardi
Sep 19, 2012·Current Oncology Reports·Azmat H Sadozye, Nicholas Reed
Oct 12, 2013·Current Oncology Reports·Tara D BarwickAndrea Rockall
Feb 13, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V Tormo FerreroR Cardenal Maciá
Jun 18, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Silvia Rodríguez VillalbaJosé Manuel Cervera Grau
Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J Alejandro Pérez FidalgoAndrés Cervantes
Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ana ReigManuel Algara
Jan 16, 2014·Indian Journal of Surgical Oncology·A S Kirthi KoushikH U Avinash
Jan 17, 2014·Journal of Obstetrics and Gynaecology of India·Uma SinghSabuhi Qureshi
Jun 30, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Cathrine M Holland, Mahmood I Shafi
May 12, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·K Van CalsterenF Amant
Apr 13, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·H Lukka, M Johnston
Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Alfonso Dueñas-GonzálezAlejandro Mohar
Dec 17, 2003·Gynecologic Oncology·Elisabeth PrasWillibrord C M Weijmar Schultz
Nov 6, 2003·Gynecologic Oncology·Jean Luc BrunClaude Hocké
Feb 7, 2002·Lancet·Jacoba van der ZeeCurt W Burger

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