Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0,Tyr3]octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors

Seminars in Nuclear Medicine
Roelf ValkemaEric P Krenning

Abstract

Because the role of chemotherapy, interferon, or somatostatin analogs as antiproliferative agents is uncertain, currently few treatment options exist for patients with metastatic or inoperable gastroenteropancreatic neuroendocrine tumors (GEP-NET). Fifty-eight patients with somatostatin receptor-positive GEP-NET were treated in a phase I dose-escalating study with cumulative doses of 47 mCi to 886 mCi of the radiolabeled somatostatin analog [(90)Y-DOTA(0),Tyr(3)]-octreotide. At baseline, 47 patients had progressive disease, and 36 were symptomatic. The extent of disease was: 4 patients without liver metastases and 52 patients with liver metastases, including 16 patients with very advanced disease, qualified as "end-stage," and 2 end-stage patients without liver metastases. The objective responses were 5 partial response (PR), 7 minor response (MR), 29 stable disease (SD), and 17 PD. Overall, 33 patients (57%) experienced some improvement in their disease status, including conversion from PD into SD and improvement from SD into MR. Accordingly, 21 of 36 patients (58%) had improvement in Karnofsky performance score or symptoms. The median overall survival (OS) was 36.7 months (95% confidence interval [CI] 19.4-54.1 months). The m...Continue Reading

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References

Sep 15, 1994·Annals of the New York Academy of Sciences·E P KrenningA E Reijs
Jan 1, 1993·Acta Oncologica·L K Kvols, J C Reubi
Apr 20, 2002·Seminars in Nuclear Medicine·Roelf ValkemaEric P Krenning
Apr 20, 2002·Seminars in Nuclear Medicine·Lowell B AnthonyKevin E McCarthy
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M HejnaM Raderer
Jan 29, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiGiovanni Paganelli
Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Siegbert FaissUNKNOWN International Lanreotide and Interferon Alfa Study Group
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaap J M TeunissenEric P Krenning
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dik J KwekkeboomEric P Krenning
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Weijing SunUNKNOWN Eastern Cooperative Oncology Group
Sep 27, 2005·Best Practice & Research. Clinical Gastroenterology·Tahir Shah, Martyn Caplin
Sep 27, 2005·Best Practice & Research. Clinical Gastroenterology·R ArnoldL Hofbauer
Oct 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rudolf ArnoldChristian N Arnold

❮ Previous
Next ❯

Citations

Sep 4, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Mattias SandströmHans Lundqvist
Mar 6, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiGiovanni Paganelli
Mar 6, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Jamshed B Bomanji, Nikolaos D Papathanasiou
Oct 13, 2006·Pituitary·Felix M Mottaghy, Sven N Reske
Jul 26, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Roberta Elisa RossiMaddalena Peracchi
Jul 31, 2013·Current Treatment Options in Oncology·Jonathan Strosberg
Mar 22, 2012·Current Oncology Reports·Diane Reidy-Lagunes, Raymond Thornton
Nov 26, 2010·Annals of Nuclear Medicine·Lutfun NisaRaffaele Giubbini
Sep 3, 2013·Annales d'endocrinologie·Eric BaudinUNKNOWN Groupe d’étude des tumeurs endocrines
Feb 5, 2009·Nature Clinical Practice. Oncology·Diane L ReidyLeonard B Saltz
Feb 11, 2011·The New England Journal of Medicine·Eric RaymondPhilippe Ruszniewski
May 6, 2008·Cancer Biotherapy & Radiopharmaceuticals·Monique de VisserMarion de Jong
Sep 6, 2008·Cancer Biotherapy & Radiopharmaceuticals·Gerald L DeNardoRod Balhorn
Sep 27, 2012·Cancer Biotherapy & Radiopharmaceuticals·Rubel ChakravartyM R A Pillai
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K E Öberg
Feb 1, 2011·American Journal of Clinical Oncology·Andrew KennedyRiad Salem
Feb 22, 2007·Neuroendocrinology·Robert T JensenUNKNOWN European Neuroendocrine Tumor Society
Jan 13, 2012·Neuroendocrinology·Esther I van VlietDik J Kwekkeboom
Jan 21, 2012·Neuroendocrinology·Gianfranco Delle FaveUNKNOWN Barcelona Consensus Conference participants
Oct 26, 2011·Endocrine-related Cancer·Jaap J M TeunissenEric P Krenning
Jun 24, 2010·World Journal of Gastroenterology : WJG·Jonathan Strosberg, Larry Kvols
Jan 12, 2012·International Journal of Hepatology·Martin Vyleta, Douglas Coldwell
Aug 31, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·John Buscombe, Shaunak Navalkissoor
Sep 14, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Amir SabetSamer Ezziddin
Jul 29, 2009·Journal of Endocrinological Investigation·L BodeiG Paganelli
Jul 24, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Esther I van VlietDik J Kwekkeboom
Nov 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Edgar J RollemanMarion de Jong
May 13, 2008·Annals of Surgical Oncology·Liselot B J van IerselCornelis J H van de Velde
Mar 29, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Sofie Van BinnebeekChristophe M Deroose
Oct 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Edgar J RollemanMarion de Jong
Dec 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Edgar J RollemanMarion de Jong
May 9, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Vikas PrasadIrvin M Modlin
Jul 30, 2014·Thoracic Surgery Clinics·Lisa BodeiGiovanni Paganelli
Mar 6, 2012·European Journal of Nuclear Medicine and Molecular Imaging·B L R KamD J Kwekkeboom
Jan 30, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Martijn van EssenDik J Kwekkeboom
Apr 26, 2014·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Sander M BisonMarion de Jong
Dec 12, 2012·International Journal of Hepatology·Mark A Lewis, Timothy J Hobday
Aug 15, 2014·European Journal of Endocrinology·Wouter A van der ZwanDik J Kwekkeboom
Jul 19, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Michael J StewardDominic Yu
Sep 23, 2011·Digestive Diseases and Sciences·M D MiljkovićR B Erlich
Feb 27, 2016·Critical Reviews in Oncology/hematology·Sara PuscedduMarina Chiara Garassino
Sep 24, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Annapaola MarinielloChiara Maria Grana
Jul 18, 2014·PET Clinics·Lisa BodeiGiovanni Paganelli

❮ Previous
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