Survival and Stability of Patients with Urothelial Cancer and Spinal Bone Metastases after Palliative Radiotherapy

Radiology and Oncology
Robert FoersterHarald Rief

Abstract

The aim of the study was to analyze survival and stability of patients with urothelial cell cancer and spinal bone metastases (SBM) after radiotherapy (RT). Furthermore, to assess the effects of RT on bone mineral density (BMD) as a local response in SBM after RT. Survival of 38 patients with 132 SBM from urothelial cancer, treated from January 2000 to January 2012, was calculated. Stability of irradiated thoracic and lumbar SBM was retrospectively evaluated in computed tomography (CT) scans using the validated Taneichi et al. score. Difference in BMD, measured in Hounsfield units (HU), of the SBM before and at 3 and 6 months after RT was analyzed. All patients died during follow-up. Overall survival (OS) after 6 months, 1 year and 2 years was 90%, 80% and 40%, respectively. Bone survival (BS) was 85%, 64% and 23% after 6 months, 1 year and 2 years, respectively. Survival from start of RT (RTS) was 42% after 6 months, 18% after 1 year and 5% after 2 years. Only 11% received bisphosphonates. Stability did not improve at 3 or 6 months after RT. BMD increased by 25.0 HU ± 49.7 SD after 3 months (p = 0.001) and by 24.2 HU ± 52.2 SD after 6 months (p = 0.037). Pain relief (> 2 points on the visual analogue scale) was achieved in onl...Continue Reading

References

Mar 21, 2007·European Urology·Takashige AbeKatsuya Nonomura
Apr 1, 2010·International Journal of Clinical Oncology·Mohamed S ZaghloulMohamed Nazmy
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Stephen LutzUNKNOWN American Society for Radiation Oncology (ASTRO)
Mar 29, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Marco BianchiQuoc-Dien Trinh
Apr 2, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ingmar SchlamppHarald Rief
Jul 12, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Harald RiefUNKNOWN German Bone Research Group
Jan 17, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ronald ChowEdward Chow

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Citations

Jun 27, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Tilman BostelNils Henrik Nicolay
Feb 18, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Wasif BalaLinda Probyn

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