Jun 10, 2004

Survival benefit conferred by topical antimicrobial preparations in burn patients: a historical perspective

The Journal of Trauma
Timothy P La H BrownA D Mason


Topical antimicrobial agents have proven efficacy in preventing life-threatening invasive burn wound infection. Under wartime or mass-casualty conditions, however, there may be an inadequate supply of these agents. This study aimed to identify those patients most likely to benefit therefrom. Logistical regression analysis of data from the U.S. Army Burn Center was performed. Mortality data for the period immediately preceding the introduction of topical mafenide acetate (MA) (1950-1963) were compared with data for the subsequent period (1964-1968). During the second period, MA was routinely applied but treatment was otherwise similar. The mortality decrement attributed to MA was determined for various ages and burn sizes. For patients of combatant age (20-50 years), MA was associated with a greater than 10% reduction in mortality for those with burns of 40-79% of the total body surface area (TBSA). Only a minimal effect on mortality was noted for those patients with burns smaller than 40% or greater than 79%. When resources are limited, topical therapy (specifically, MA) is likely to confer the greatest survival benefit for combatants with burns of 40-79% TBSA.

  • References12
  • Citations23


  • References12
  • Citations23


Mentioned in this Paper

Disaster Relief Planning
Logistic Regression
Administration, Topical
Microbicides, Topical
Mafenide Acetate
Regression Analysis
Retrospective Studies

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