Survival benefit for adjuvant radiation therapy in minor salivary gland cancers

Oral Oncology
Youssef H ZeidanQuynh-Thu Le

Abstract

The goal of the current study is to investigate the role of adjuvant radiation therapy (adjuvant RT) in minor salivary gland tumors (mSGT) using an established national database. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients treated with or without adjuvant RT for mSGT from 1988 to 2008. Regression analyses were performed to identify factors associated with improved overall survival (OS). Most tumors were located within the oral cavity (75%) followed by nasal cavity/paranasal sinuses (15%). Multivariate Cox analysis showed that adjuvant RT was associated with better OS compared to surgery alone. Using logistic regression analysis, we provide a novel web based tool for predicting survival impact of adjuvant RT in patients with mSGT. Adjuvant RT is associated with improved survival in patients with mSGT and adverse clinicopathologic factors such as advanced T/N category, adenoid cystic histology, high grade, and nasopharynx location.

References

Jun 1, 1996·International Journal of Radiation Oncology, Biology, Physics·F Eschwege
Oct 13, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J B EpsteinN Le
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Chris H J TerhaardUNKNOWN Dutch Head and Neck Oncology Cooperative Group
Jan 7, 2005·American Journal of Otolaryngology·Neil Bhattacharyya, Marvin P Fried
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sébastien J HotteLillian L Siu
Oct 15, 2008·Head & Neck·Kwok Seng LohJonathan C Irish
Jun 10, 2009·The Laryngoscope·Marco CianchettiWilliam M Mendenhall
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marta PerssonGöran Stenman
Nov 27, 2009·Critical Reviews in Oncology/hematology·Marco GuzzoLisa Licitra
Aug 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshitsugu MitaniAdel K El-Naggar
Sep 8, 2011·International Journal of Ayurveda Research·Sanjeev Sarmukaddam
Jun 13, 2012·Seminars in Radiation Oncology·David J AdelsteinEhab Y Hanna
Feb 23, 2013·American Journal of Clinical Oncology·Lucas R SalgadoNancy Y Lee

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Citations

Nov 26, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Robert J LeeRussell E Christensen
May 22, 2016·Oral Oncology·J Rhet TuckerKatherine A Hutcheson
Jul 11, 2016·Oral Oncology·Ester OrlandiPiero Fossati
May 10, 2018·Cancer·Katri AroZachary S Zumsteg
Feb 6, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Katri AroZachary S Zumsteg
Dec 20, 2016·Oncotarget·Xiaoli WangTingyong Fan
Feb 11, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Monali SwainJai Prakash Agarwal
Aug 27, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Viola FreitagMarlen Haderlein

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