Survival benefit for patients with advanced-stage transitional cell carcinomas vs. other subtypes of ovarian carcinoma after chemotherapy with platinum and paclitaxel

Gynecologic Oncology
Friedrich KommossArbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom

Abstract

Transitional cell carcinoma (TCC) of the ovary is a less well recognized histological type of ovarian carcinoma resembling TCC of the urinary bladder. A better prognosis due to a better chemosensitivity of ovarian TCC has been suggested. It was the aim of the present retrospective study to compare incidence and outcome of patients with TCCs and other subtypes of ovarian carcinoma from a large homogeneous collective of patients with primary advanced-stage ovarian carcinoma. H and E-stained sections from a total of 302 cases from a prospective randomized, multi-center, phase III study of patients with ovarian cancer, FIGO-stages IIB-IV, comparing cisplatin plus paclitaxel (PT) with paclitaxel plus carboplatin (TC) were available for histological retyping of ovarian carcinomas applying current WHO criteria. Kaplan-Meier survival analysis was performed. 16 of 302 tumors (5.3%) were diagnosed as TCC. Only 1 of the 16 TCCs had been previously diagnosed as such by referring pathologists. TCCs were associated with smaller preoperative extraovarian tumor and with smaller postoperative residual tumor. 5-year survival of patients with TCC was 57% as compared to 31% for patients with ovarian carcinomas of other types (P = 0.03). TCC of the...Continue Reading

References

Jul 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R A SoslowT A Longacre
Dec 1, 1996·Human Pathology·H C HollingsworthM J Merino
Aug 26, 1999·The British Journal of Ophthalmology·J M MAcKENZIE
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Viviane HessMartin E Gore

❮ Previous
Next ❯

Citations

Mar 1, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M Carolina ReyesRobert A Soslow
Nov 16, 2010·World Journal of Surgical Oncology·E M TaziH Errihani
Jan 11, 2013·Science Translational Medicine·Isaac KindeLuis A Diaz
Dec 24, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert A SoslowDouglas A Levine
Apr 8, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M DolanbayI S Serin
Nov 1, 2011·Journal of the Chinese Medical Association : JCMA·Yiu-Tai LiWen-Ling Lee
May 10, 2011·Journal of the Chinese Medical Association : JCMA·Chung-Cheng YuYang-Tse Shih
Jun 26, 2009·Human Pathology·C Blake Gilks, Jaime Prat
Jul 18, 2009·Annals of Diagnostic Pathology·Danielle WestfallElvio G Silva
Sep 18, 2014·The Journal of Obstetrics and Gynaecology Research·Puja SahaiSubhash Chander
Apr 30, 2016·International Journal of Applied & Basic Medical Research·Shirish S ChandanwaleRahul Jadhav
Jan 28, 2014·Gynecologic Oncology·Stephanie H GusehMarcela G del Carmen
Sep 16, 2016·British Journal of Cancer·Stefan KommossFriedrich Kommoss
Jan 25, 2014·Journal of Gynecologic Oncology·Hiroaki KajiyamaFumitaka Kikkawa
Oct 14, 2011·Advances in Anatomic Pathology·Carmen Bárcena, Esther Oliva
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dimitrios NasioudisMariarosaria Di Tommaso
Aug 2, 2007·The American Journal of Surgical Pathology·Lawrence M Roth
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Nicolas WentzensenFriedrich Kommoss
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jeffrey D SeidmanJonathan A Cosin
Apr 22, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Martin KöbelUNKNOWN Cheryl Brown Ovarian Cancer Outcomes Unit of the British Columbia Cancer Agency, Vancouver BC
Aug 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Helen J MackayUNKNOWN Gynecologic Cancer InterGroup
Sep 29, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rola H AliC Blake Gilks
Jul 27, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Amy B BromleyMartin Köbel
Jul 31, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jamie MagrillFriedrich Kommoss
Jun 29, 2012·Oncology Letters·Satoshi IchigoAtsushi Imai
Oct 30, 2020·Frontiers in Oncology·Anjelica Hodgson, Gulisa Turashvili

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved