Survival benefit of chemoembolization plus Iodine125 seed implantation in unresectable hepatitis B-related hepatocellular carcinoma with PVTT: a retrospective matched cohort study

European Radiology
Mingsheng HuangHong Shan

Abstract

To investigate the survival benefit of transarterial chemoembolization (TACE) plus Iodine125 seed implantation (TACE-Iodine125) in hepatitis B-related HCC patients with portal vein tumour thrombus (PVTT) and the underlying prognostic factors. A retrospective matched cohort study was performed on consecutive HCC patients with PVTT from January 2011 to June 2014. Seventy patients (TACE-Iodine125 group) who underwent TACE-Iodine125 were compared with a historical case-matched control group of 140 patients (TACE group) who received TACE alone. The survival of patients and the underlying prognostic factors were analysed. The median survival times of the TACE-Iodine125 and TACE groups were 11.0 and 7.5 months, respectively (p < 0.001). The survival probability at 12, 24, and 36 months was 50 %, 14.5 %, and 14.5 % vs. 25 %, 9 %, and 5 % in the TACE-Iodine125 and TACE groups, respectively (p < 0.001). The PVTT responders had better survival than the PVTT non-responders (p < 0.001). For the PVTT non-responders, there were no differences in the survival curves between the groups (p = 0.353). Multivariate analysis showed that type III PVTT (p < 0.001) and APS (p < 0.001) were independent predictors of poor prognosis. In contrast, the trea...Continue Reading

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References

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Dec 24, 2005·Journal of Vascular and Interventional Radiology : JVIR·Christos S GeorgiadesJean-Francois H Geschwind
Dec 7, 2007·Journal of Vascular and Interventional Radiology : JVIR·Nishita KotharyJohn H Rundback
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Jan 30, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giuseppe CabibboCalogero Cammà
Feb 5, 2010·Annals of Surgical Oncology·Jie ShiShu-Qun Cheng
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Aug 14, 2010·BMJ : British Medical Journal·Martin Duerden
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruno SangroUNKNOWN European Network on Radioembolization with Yttrium-90 Resin Microspheres (ENRY)
May 31, 2011·International Journal of Radiation Oncology, Biology, Physics·Sang Min YoonDong Jin Suh
Aug 6, 2011·Journal of Hepatology·Bruno SangroJose I Bilbao
Sep 14, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ghassan K Abou-Alfa
Apr 16, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabio PiscagliaLuigi Bolondi
Apr 17, 2013·Nuclear Medicine Communications·Alina Lintia-GaultierEric Frampas

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Citations

Sep 1, 2018·Cardiovascular and Interventional Radiology·Chen WangCaifang Ni
Jan 16, 2020·Journal of Cancer Research and Therapeutics·Zhaomin SongWujie Wang
May 2, 2019·World Journal of Gastrointestinal Oncology·Yue ZhangFu-Quan Liu
Aug 8, 2019·The Lancet. Gastroenterology & Hepatology·Jian LuGao-Jun Teng
Jan 19, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S LiR Fan

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