Survival benefit of cirrhotic patients with hepatocellular carcinoma treated by percutaneous ethanol injection as a salvage therapy

Scandinavian Journal of Gastroenterology
Teh-Ia HuoShou-Dong Lee

Abstract

The therapeutic strategy for cirrhotic patients with hepatocellular carcinoma (HCC) who cannot tolerate surgery or transcatheter arterial chemoembolization (TACE) is uncertain. The safety and efficacy of percutaneous ethanol injection (PEI) as a salvage therapy in such patients is not clear. A total of 63 (49 men) HCC patients (mean age 67 +/- 11 years), for whom surgery or TACE was not indicated because of the coexistence of various medical conditions, were enrolled and prospectively studied. Fifty-six (89%) were treated with PEI and 7 were treated with conservative measures. The outcome and the factors that may affect survival were evaluated. During a mean follow-up period of 16 +/- 9 months, 17 (30%) of the patients treated with PEI and 5 (71%) of those treated with conservative measures died (P = 0.045). A total of 16 patient-related and tumor-related variables that may influence the outcome were analyzed. Survival analysis showed that female gender, small (< or = 3 cm) solitary tumor and PEI were associated with a better prognosis (P < 0.05). When using the Cox proportional hazard model, PEI was the only significant independent factor predicting survival (relative risk: 0.3, 95% confidence interval: 0.11-0.86, P = 0.024). ...Continue Reading

Citations

Aug 5, 2009·World Journal of Gastroenterology : WJG·Ke-Cheng XuJian-Sheng Zuo
Apr 27, 2005·Journal of the Chinese Medical Association : JCMA·Teh-Ia HuoJaw-Ching Wu
Apr 20, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M C JansenT M van Gulik
Jan 27, 2015·The Cochrane Database of Systematic Reviews·Sebastian WeisKonrad Schoppmeyer
Nov 4, 2010·Journal of Gastrointestinal Cancer·Alaa IsmailAbdulhafez Selim
Sep 13, 2003·World Journal of Gastroenterology : WJG·Jun QianThomas Vogl
Nov 10, 2004·World Journal of Gastroenterology : WJG·Yong-Song GuanXiao-Hua Zheng

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