Survival benefit of multimodal local therapy for repeat recurrence of thoracic esophageal squamous cell carcinoma after esophagectomy

Esophagus : Official Journal of the Japan Esophageal Society
Itasu NinomiyaTetsuo Ohta

Abstract

This study was performed to clarify the optimal therapeutic strategy for recurrent disease after esophagectomy. We investigated the prognosis of 37 patients who developed recurrence among 128 patients who underwent curative thoracoscopic esophagectomy (TE) at Kanazawa University Hospital. The prognostic factors after recurrence were examined by univariate and multivariate analyses. Of these 37 recurrences, 29 patients underwent local therapy (surgery, 10 patients; surgery followed by radiation, 2 patients; radiation, 17 patients). Radiation includes intensity-modulated radiation therapy, chemoradiation, and simple radiation therapy. Seventeen patients (58.6%) were considered to have undergone successful therapy by disappearance or diminishment of the targeted region without regrowth. Eleven of 17 patients (64.7%) showed repeat recurrence at another site. Multiple local therapy was performed for repeat recurrence or uncontrollable first therapy. Finally, 57 local therapies were performed. Using multimodal local therapy, 37 (64.9%) of 57 recurrences were successfully managed. The 12 patients treated by surgery as the initial therapy showed the most favorable survival. Seventeen patients who underwent successful initial therapy sh...Continue Reading

References

Nov 3, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C M NuttingS Webb
Feb 5, 2004·Journal of the American College of Surgeons·Satoru NakagawaKatsuyoshi Hatakeyama
Nov 22, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anurag ChandraRitsuko Komaki
Apr 29, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M YanoS Imaoka
Mar 15, 2008·General Thoracic and Cardiovascular Surgery·Itasu NinomiyaTetsuo Ohta
Jul 2, 2008·Annals of Surgical Oncology·Tsutomu NakamuraNorio Mitsuhashi
Jun 17, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M WatanabeH Baba
Oct 4, 2012·Journal of Cardiothoracic Surgery·Masashi TakemuraKayo Yoshida
Apr 5, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R KobayashiK Nakagawa

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