Survival benefit of neoadjuvant chemotherapy for resectable breast cancer: A meta-analysis

Medicine
Yan ChenKe-Hu Yang

Abstract

Neoadjuvant chemotherapy (NAC) increases breast conservation rates in patients with resectable breast cancer at the associated cost of higher locoregional recurrence rates; however, the magnitude of the survival benefits of NAC for these patients remains undefined. Therefore, we aimed to clarify the survival benefit of NAC versus postoperative chemotherapy by conducting an updated meta-analysis of randomized clinical trials (RCTs). The authors searched the Cochrane Library, PubMed, Embase, Web of Science, Chinese biomedical literature database, and Chinese Scientific Journals full-text database from their inception to December 2016. The authors identified relevant RCTs that compared NAC with postoperative chemotherapy in the treatment of operable breast cancer. The main endpoints were overall survival (OS) and recurrence-free survival (RFS). A total of 21 citations representing 16 unique studies were eligible. There were 787 deaths among 2794 patients assigned to NAC groups and 816 deaths among 2799 patients assigned to adjuvant chemotherapy groups. A meta-analysis of data indicated that there was no significant benefit in terms of OS ([hazard ratio [HR] = 1.03, 95% confidence interval [CI]: 0.94-1.13, P = .51) and RFS (HR = 1....Continue Reading

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Citations

Mar 28, 2020·Current Breast Cancer Reports·Julie K JangNaomi R Schechter
Nov 8, 2018·Nature Medicine·Caroline Robert
May 22, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jose Carlos BenitezBenjamin Besse
Nov 11, 2021·American Journal of Therapeutics·Teng MaHai-Bo Wang

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