Survival benefit of neoadjuvant chemotherapy in non-small cell lung cancer: an updated meta-analysis of 13 randomized control trials

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Wei-An SongWei-Min Dai

Abstract

The survival effectiveness of neoadjuvant chemotherapy in non-small cell lung cancer (NSCLC) is still unclear based on the study of most up-to-date literatures. This article contributes to this problem by conducting an updated meta-analysis. Based on Burdett et al's (J Thorac Oncol 2006;1:611-621) systematic review, this meta-analysis was conducted. Articles were searched electrically. The possible survival benefit of neoadjuvant chemotherapy was assessed by hazard ratio (HR) in terms of overall survival. A subgroup meta-analysis with only stage III NSCLC was also conducted. The software of Review Manager was used for data management. Thirteen randomized control trials, 6 of which were new ones, were included into this meta-analysis. The overall survival of NSCLC patients in neoadjuvant chemotherapy arm were improved significantly, comparing with those in surgery-alone arm (combined HR = 0.84; 95% confidence interval, 0.77-0.92; p = 0.0001). When only patients with stage III NSCLC were considered, the result was similar (combined HR = 0.84; 95% confidence interval, 0.75-0.95; p = 0.005). Neoadjuvant chemotherapy, as an addition of surgery, would significantly improve the overall survival of operable NSCLC patients, including pa...Continue Reading

References

Jun 1, 1992·The Annals of Thoracic Surgery·H I PassJ Minna
Apr 1, 1995·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J L PujolF B Michel
Aug 28, 1996·JAMA : the Journal of the American Medical Association·C BeggD F Stroup
Nov 26, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R RosellJ Roig
Dec 18, 2001·Seminars in Surgical Oncology·S B HoschJ R Izbicki
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alain DepierreUNKNOWN French Thoracic Cooperative Group
Apr 23, 2002·Current Medicinal Chemistry·Enriqueta Felip, Rafael Rosell
Feb 1, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C LequaglieG Giudice
Sep 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Noriyoshi SawabataUNKNOWN Japan National Chest Hospital Study Group for Lung Cancer
Jun 1, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F De MarinisL De Petris
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T BerghmansJ P Sculier
Mar 23, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daniel C Betticher
Apr 22, 2006·PLoS Medicine·Hisayuki ShigematsuMakoto Suzuki
Jun 30, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A SantoG L Cetto
Sep 22, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Haruhiko NakamuraKazuyuki Kabasawa
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sarah BurdettLarysa Rydzewska
Jun 2, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Julie R Brahmer, David S Ettinger
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George SimonGerold Bepler
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephanie SmithDionyssios Katsaros
Sep 23, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Adam Vilmar, Jens Benn Sørensen

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Citations

Apr 2, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joachim SchirrenServet Bölükbas
Aug 27, 2013·Lancet·Martin ReckKlaus F Rabe
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Besse, T Le Chevalier
Jan 8, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Filippo LococoPierluigi Granone
Sep 10, 2011·Therapeutic Advances in Medical Oncology·Georgios IoannidisJohn Souglakos
Aug 11, 2012·World Journal of Surgical Oncology·Hakan BozcukUNKNOWN Lung Cancer Committee of Turkish Oncology Group
Dec 3, 2014·Thoracic Surgery Clinics·Jessica S Donington, Harvey I Pass
Nov 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sandra P D'AngeloChristopher G Azzoli
Aug 16, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Farhood FarjahNabil P Rizk
Apr 11, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mark F BerryIgor Akushevich
Aug 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jamie E ChaftChristopher G Azzoli
Jan 5, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William N WilliamUNKNOWN University of Texas M.D. Anderson Lung Cancer Collaborative Research Group
Oct 21, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Patrick MickeJohan Botling
Apr 7, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Apar PataerUNKNOWN University of Texas M. D. Anderson Lung Cancer Collaborative Research Group
Apr 7, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ichiro YoshinoUNKNOWN Japanese Joint Committee of Lung Cancer Registration
Jun 23, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Guillaume MouilletUNKNOWN Intergroupe Francophone de Cancérologie Thoracique (IFCT)
Dec 24, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel Morgensztern, Ramaswamy Govindan
Aug 13, 2013·The Annals of Thoracic Surgery·Benjamin IzarMichael Lanuti
Aug 13, 2013·Thoracic Surgery Clinics·R Taylor Ripley, Valerie W Rusch
May 29, 2012·The Annals of Thoracic Surgery·Asad A ShahThomas A D'Amico
Apr 24, 2012·Thoracic Surgery Clinics·Ramón Rami-Porta, Sergi Call
Jul 6, 2011·Seminars in Roentgenology·Eithne Delappe, Mark Dunphy
Aug 27, 2014·Interactive Cardiovascular and Thoracic Surgery·Yong-jie XuKe Fei
Aug 12, 2014·Expert Opinion on Pharmacotherapy·Masaaki Kawahara
Sep 10, 2014·Pathology Oncology Research : POR·Eszter PodmaniczkyJudit Moldvay
Sep 25, 2012·International Journal of Radiation Oncology, Biology, Physics·Ramesh GopalCorey J Langer
Jan 5, 2014·The Lancet Oncology·Matthew D HellmannUNKNOWN University of Texas MD Anderson Lung Cancer Collaborative Group
Apr 18, 2015·The Urologic Clinics of North America·Arjun V Balar, Matthew I Milowsky
Nov 7, 2014·Cancer Chemotherapy and Pharmacology·Hyun-ju LimYoung Mog Shim
May 31, 2016·Archivos de bronconeumología·Felipe Villar ÁlvarezJavier J Zulueta
Jul 28, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M D HellmannM G Kris
Jul 17, 2016·Revue de pneumologie clinique·M RiquetE Fabre
Oct 19, 2016·The Journal of Thoracic and Cardiovascular Surgery·Preethi S ShettyC S Pramesh

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