Survival benefits and trends in use of adjuvant therapy among elderly stage II and III rectal cancer patients in the general population

Cancer
Sharon A DobieKevin Billingsley

Abstract

This study examined elderly stage II and III rectal cancer patients' adjuvant chemoradiation therapy adherence, trends in adherence over time, and the relation of levels of adherence to mortality. The authors studied 2886 stage II and III rectal cancer patients who had surgical resection and who appeared in 1992-1999 linked SEER-Medicare claims data. The authors compared measures of adjuvant radiation and chemotherapy receipt and completion between stage II and III patients. Adjusted risk of cancer-related 5-year mortality was calculated by multivariate logistic regression for different levels of chemoradiation adherence among stage II and III patients. Of the 2886 patients, 45.4% received both adjuvant radiation and chemotherapy. Stage III patients were more likely to receive chemoradiation than stage II patients. The receipt of chemoradiation by stage II patients increased significantly from 1992 to 1999. Stage III patients were more likely to complete radiation therapy (96.6%), chemotherapy (68.2%), and both modalities (67.5%) than stage II patients (91.5%, 49.8%, 47.6%, respectively). Only a complete course of both radiation and chemotherapy for both stage II (relative risk [RR] 0.74; 95% CI, 0.54, 0.97) and III (RR 0.80; 9...Continue Reading

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References

Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D MinskyJ Frankel
Mar 14, 1991·The New England Journal of Medicine·J E KrookJ A Mailliard
Sep 19, 1990·JAMA : the Journal of the American Medical Association
Jun 6, 1985·The New England Journal of Medicine·UNKNOWN Gastrointestinal Tumor Study Group
Nov 13, 1986·The New England Journal of Medicine·H O DouglassUNKNOWN Gastrointestinal Tumor Study Group
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·N R AhmadM Mohiuddin
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J O'ConnellA Figueredo
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·R C MillerJ E Krook
Aug 26, 1998·Archives of Surgery·R J HealdJ K MacFarlane
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E TepperR J Mayer
Sep 5, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D SchragC B Begg
Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnold L PotoskyCharles F Lynch
Mar 7, 2002·Medical Care·Elizabeth B LamontNicholas A Christakis
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E TepperR J Mayer
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfred I NeugutVictor R Grann
Jun 10, 2003·International Journal of Gastrointestinal Cancer·Melina W Dharma-WardeneJuanita Hatcher
Aug 9, 2003·The British Journal of Surgery·S BülowUNKNOWN RANX05 Colorectal Cancer Study Group
Oct 1, 2003·International Journal of Colorectal Disease·G ValeroP Parrilla
Feb 11, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederick L GreeneH James Norton
Apr 7, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard L GundersonRichard M Goldberg
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Nov 17, 2005·Journal of the National Cancer Institute·Seung-Yong JeongJose G Guillem
May 4, 2006·Journal of the National Cancer Institute·Sharon A DobieWilliam Barlow
Oct 13, 2006·The American Journal of Gastroenterology·Deirdre P CroninMargaret M Mooney

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Citations

Jun 10, 2009·Current Treatment Options in Oncology·Lilie L Lin, Stephen M Hahn
Mar 19, 2009·Journal of Gastrointestinal Cancer·John S MoodyJames A Bonner
Jun 9, 2010·The Cancer Journal·Derek G Power, Stuart M Lichtman
Sep 28, 2013·Journal of Geriatric Oncology·Gerald C BohacKevan L Hartshorn
Sep 17, 2011·Annals of Surgical Oncology·E KreiterM Winget
Nov 15, 2011·Medical Care·Jennifer L LundJoan L Warren
Jan 16, 2010·Cancer Investigation·Benjamin LebwohlAlfred I Neugut
Dec 15, 2015·The British Journal of Surgery·C A ThielsK L Mathis
Sep 19, 2012·Seminars in Radiation Oncology·Jennifer Y WoLisa A Kachnic
Aug 2, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·N Sharaf EldinM Winget
Mar 8, 2011·International Journal of Radiation Oncology, Biology, Physics·Danielle N MargalitTheodore S Hong
Feb 5, 2010·The American Journal of Geriatric Pharmacotherapy·Nour A ObeidatC Daniel Mullins
Jul 1, 2009·Journal of the American Geriatrics Society·Ilene H ZuckermanC Daniel Mullins
Jun 8, 2012·Australian and New Zealand Journal of Public Health·Bridie ThompsonMichael Coory
Feb 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Henry S ParkJames B Yu
Jun 26, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Kathy L SchulmanAlex Shteynshlyuger
Jan 16, 2009·Critical Reviews in Oncology/hematology·Jaime Gomez-Millan
Aug 22, 2013·Journal of the National Cancer Institute. Monographs·Eboneé N ButlerK Robin Yabroff
Apr 26, 2017·Medical Oncology·Robert Díaz BeveridgeJorge Aparicio
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Nadine Jackson McClearyRodrigo Dienstmann
Oct 30, 2021·Molecular and Clinical Oncology·Sharlyn KangStephanie Hui-Su Lim

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