Survival by Histologic Subtype of Malignant Pleural Mesothelioma and the Impact of Surgical Resection on Overall Survival

Clinical Lung Cancer
Vivek VermaCharles B Simone

Abstract

For the 3 histologic subtypes of malignant pleural mesothelioma (MPM)-epithelioid, sarcomatoid, and biphasic-the magnitude of benefit with surgical management remains underdefined. The National Cancer Data Base was queried for newly diagnosed nonmetastatic MPM with known histology. Patients in each histologic group were dichotomized into those receiving gross macroscopic resection versus lack thereof/no surgery. Kaplan-Meier analysis evaluated overall survival (OS) between cohorts; multivariable Cox proportional hazards modeling assessed factors associated with OS. After propensity matching, survival was evaluated for each histologic subtype with and without surgery. Overall, 4207 patients (68% epithelioid, 18% sarcomatoid, 13% biphasic) met the study criteria. Before propensity matching, patients with epithelioid disease experienced the highest median OS (14.4 months), followed by biphasic (9.5 months) and sarcomatoid (5.3 months) disease; this also persisted after propensity matching (P < .001). After propensity matching, surgery was associated with significantly improved OS for epithelioid (20.9 vs. 14.7 months, P < .001) and biphasic (14.5 vs. 8.8 months, P = .013) but not sarcomatoid (11.2 vs. 6.5 months, P = .140) disease...Continue Reading

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Citations

Apr 24, 2019·Annals of Surgical Oncology·Vivek VermaCharles B Simone
Dec 19, 2020·Clinical and Experimental Pharmacology & Physiology·Rajesh M JagirdarSotirios G Zarogiannis
Oct 18, 2019·The Journal of Thoracic and Cardiovascular Surgery·Lloyd M Felmly, Barry C Gibney
Nov 27, 2020·Therapeutic Advances in Medical Oncology·Haitang YangRen-Wang Peng
Jul 3, 2020·Clinical Lung Cancer·Andrew R BarskyCharles B Simone
Oct 6, 2020·Thoracic Surgery Clinics·Yin P Hung, Lucian R Chirieac
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Sep 15, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Emily S ReardonDavid S Schrump
Oct 15, 2021·Veterinary and Comparative Oncology·Hanne Larsen MobergAlexandra Guillén

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