Survival impact of time to initiation of chemoradiotherapy after resection of newly diagnosed glioblastoma

Journal of Neurosurgery
Matthew Z SunOrin Bloch

Abstract

OBJECT There are few and conflicting reports on the effects of delayed initiation of chemoradiotherapy on the survival of patients with glioblastoma. The standard of care for newly diagnosed glioblastoma is concurrent radiotherapy and temozolomide chemotherapy after maximal safe resection; however, the optimal timing of such therapy is poorly defined. Given the lack of consensus in the literature, the authors performed a retrospective analysis of The Cancer Genome Atlas (TCGA) database to investigate the effect of time from surgery to initiation of therapy on survival in newly diagnosed glioblastoma. METHODS Patients with primary glioblastoma diagnosed since 2005 and treated according to the standard of care were identified from TCGA database. Kaplan-Meier and multivariate Cox regression analyses were used to compare overall survival (OS) and progression-free survival (PFS) between groups stratified by postoperative delay to initiation of radiation treatment. RESULTS There were 218 patients with newly diagnosed glioblastoma with known time to initiation of radiotherapy identified in the database. The median duration until therapy was 27 days. Delay to radiotherapy longer than the median was not associated with worse PFS (HR = 0...Continue Reading

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Citations

Jan 23, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Guillaume LouvelUNKNOWN Club de Neuro-Oncologie of Société Française deNeurochirurgie
Oct 10, 2015·Journal of Neurosurgery·Sandeep S Bhangoo
Jun 20, 2015·Journal of Neurosurgery·James T Rutka
Jan 7, 2017·Journal of Neurosurgery·Masaaki KouchiTakashi Tamiya
Jan 20, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Amedeo A AziziIrene Slavc
May 1, 2019·Radiation Oncology·Sotirios KatsigiannisPantelis Stavrinou
Jul 1, 2020·Journal of Neuro-oncology·Na Tosha N GatsonVinay K Puduvalli
Sep 30, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chigang DuQi Pang
Jun 2, 2017·Journal of Neuro-oncology·Javier E Villanueva-MeyerNicholas A Butowski
May 1, 2018·Neuro-oncology Practice·Ruichong MaUNKNOWN British Neurosurgical Trainee Research Collaborative
Mar 10, 2019·Journal of Neuro-oncology·Vanessa Montes SantosOlavo Feher
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Łukasz MagrowskiMarcin Miszczyk
Sep 9, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Johannes KasperJürgen Meixensberger

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