Survival in cancer patients hospitalized for inflammatory bowel disease in Sweden

Inflammatory Bowel Diseases
Xiaochen ShuK Hemminki

Abstract

The increased cancer risk among patients diagnosed with inflammatory bowel disease (IBD) is well reported, whereas studies regarding the cancer prognosis with IBD have shown conflicting results. We aimed at assessing and quantifying the cause-specific and overall mortality among cancer patients with IBD compared to those without IBD. The population-based Swedish registers were used to identify cancer patients diagnosed with or without IBD. We used a Cox regression model to estimate hazard ratios (HRs) for cause-specific and overall mortality, showing the probability of death in the study group compared to the reference. A total of 2462 cancer patients with IBD and 1,011,894 cancer patients without IBD were ascertained from 1964 to 2006, showing a significant survival disparity (overall HR, 1.26; 95% confidence interval [CI]: 1.20-1.33 versus cause-specific HR, 1.22; 95% CI: 1.15-1.29). Although worse overall cancer mortality with IBD was widely observed, the worse cause-specific mortality was only confined to colorectal cancer (CRC). There was no difference in TNM staging among cancer patients with or without IBD. Stratified analyses showed that a worse prognosis was more pronounced in younger patients (<60 years) and in men. D...Continue Reading

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Citations

Jan 10, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K HemminkiK Sundquist
Oct 4, 2012·Journal of Hematology & Oncology·Kari HemminkiKristina Sundquist
Mar 29, 2012·Digestive Diseases and Sciences·Wojciech Blonski, Gary R Lichtenstein
Dec 12, 2012·The Journal of Urology·Xiangdong LiuKari Hemminki
Dec 17, 2014·Clinical Endoscopy·Song I Bae, You Sun Kim
Aug 25, 2017·Inflammatory Bowel Diseases·Loes H C NissenAndrea E van der Meulen-de Jong
Apr 10, 2013·British Journal of Haematology·Kari HemminkiKristina Sundquist
Apr 4, 2015·World Journal of Gastroenterology : WJG·Yong Sik YoonUNKNOWN Korean Society of Coloproctology
Jan 25, 2017·Journal of Clinical Periodontology·Spyridon N PapageorgiouJames Deschner
Jan 16, 2019·Therapeutic Advances in Gastroenterology·Shaji Sebastian, Steven Neilaj
Nov 21, 2020·Diseases of the Colon and Rectum·Ahmad AlsughayerAmy L Lightner
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K HemminkiK Sundquist

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