Survival in HIV-positive transplant recipients compared with transplant candidates and with HIV-negative controls

AIDS
Michelle RolandHIVTR Study Team

Abstract

To evaluate the impact of liver and kidney transplantation on survival in HIV-positive transplant candidates and compare outcomes between HIV-positive and negative recipients. Observational cohort of HIV-positive transplant candidates and recipients and secondary analysis comparing study recipients to HIV-negative national registry controls. We fit proportional hazards models to assess transplantation impact on mortality among recipients and candidates. We compared time to graft failure and death with HIV-negative controls in unmatched, demographic-matched, and risk-adjusted models. There were 17 (11.3%) and 46 (36.8%) deaths among kidney and liver recipients during a median follow-up of 4.0 and 3.5 years, respectively. Transplantation was associated with survival benefit for HIV-infected liver recipients with model for end-stage liver disease (MELD) greater than or equal 15 [hazard ratio (HR) 0.1; 95% confidence interval (CI) 0.05, 0.01; P < 0.0001], but not for MELD less than 15 (HR 0.7; 95% CI 0.3, 1.8; P = 0.43) or for kidney recipients (HR 0.6; 95% CI 0.3, 1.4; P = 0.23). In HIV-positive kidney recipients, unmatched and risk-matched analyses indicated a marginally significant HR for graft loss [1.3 (P = 0.07) and HR 1.4 (P...Continue Reading

References

Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriel C OniscuJohn L R Forsythe
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert S Brown, John R Lake
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert M MerionRobert A Wolfe
Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Santiago MorenoAdolfo Martínez
Apr 29, 2005·Journal of the American Society of Nephrology : JASN·Gabriel C OniscuJohn L R Forsythe
Dec 8, 2005·JAMA : the Journal of the American Medical Association·Robert M MerionFriedrich K Port
Sep 5, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·George N Ioannou
Feb 14, 2007·Transplantation·Lluis CastellsCarlos Margarit
Aug 19, 2007·Transplantation Proceedings·G VennarecciE Santoro
Sep 26, 2007·Transplantation·Ian SchreibmanArie Regev
Dec 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean-Charles Duclos-ValléeUNKNOWN THEVIC Study Group
Jan 15, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D E SchaubelR M Merion
Sep 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Javier MurillasUNKNOWN ESLD-HIV Working Group Investigators
Oct 28, 2009·Transplantation Proceedings·C BillaultB Barrou
Mar 30, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C S CoffinN A Terrault
Aug 12, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Amanda MocroftUNKNOWN EuroSIDA Study Group
Sep 16, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M TouzotM N Peraldi
Nov 19, 2010·The New England Journal of Medicine·Peter G StockMichelle E Roland
May 31, 2011·Transplantation Proceedings·F Di BenedettoG E Gerunda
Sep 8, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Asunción MorenoUNKNOWN OLT-HIV FIPSE Cohort Investigators
Dec 31, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vasantha JotwaniMichael G Shlipak
Feb 14, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Norah A TerraultUNKNOWN Solid Organ Transplantation in HIV: Multi-Site Study Investigators
Apr 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M MiroUNKNOWN Spanish OLT in HIV-Infected Patients Working Group investigators
Jul 31, 2013·Current HIV/AIDS Reports·Jack HarbellPeter Stock
Jan 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·María Luisa Montes RamírezUNKNOWN GESIDA 3703.FIPSE 36466503-N5 NEAT Study Group

❮ Previous
Next ❯

Citations

Jan 9, 2019·Kidney Research and Clinical Practice·Jakapat VanichananKamonwan Jutivorakool
Jul 7, 2018·Current Treatment Options in Infectious Diseases·Ashton A Shaffer, Christine M Durand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
C L BergJames E Everhart
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Robert M MerionRobert A Wolfe
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M E de VeraMargaret Ragni
© 2022 Meta ULC. All rights reserved