Survival in patients on hemodialysis: Effect of gender according to body mass index and creatinine

PloS One
Jeung-Min ParkClinical Research Center for End Stage Renal Disease (CRC for ESRD) Investigators

Abstract

The association of a higher body mass index (BMI) with better survival is a well-known "obesity paradox" in patients on hemodialysis (HD). However, men and women have different body compositions, which could impact the effect of BMI on mortality. We investigated the effect of gender on the obesity-mortality relationship in Korean patients on HD. This study included 2,833 maintenance patients on HD from a multicenter prospective cohort study in Korea (NCT00931970). The relationship between categorized BMI and gender-specific mortality was evaluated by an adjusted Cox proportional hazard model with restricted cubic spline analyses and the Competing risk analysis. We also investigated the effect of changes in BMI over 12 months and serum creatinine level on survival in male and female patients on HD. The mean BMI was 22.6 ± 3.3 kg/m2 and the mean follow up duration was 24.2 ± 3.4 months. The patients with the highest quintile of BMI (≥25.1 kg/m2) showed lower mortality (subdistributional hazard ratio [SHR] = 0.63, 95% confidence interval [CI] = 0.43-0.93, P = 0.019) compared with those with the reference BMI quintile. When analyzed by gender, male patients with a BMI over 25.1 kg/m2 had lower mortality risk (HR = 0.43, 95% CI = 0....Continue Reading

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Citations

Feb 18, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Saulo Barbosa Vasconcelos de AlencarKátia Cristina Lima de Petribú
Dec 10, 2020·International Journal of Environmental Research and Public Health·Marios SpanakisAthina Patelarou

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Clinical Trials Mentioned

NCT00931970

Software Mentioned

R
SAS

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