Survival of a surgical series of lung cancer patients with synchronous multiple ground-glass opacities, and the management of their residual lesions

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Yoshihisa ShimadaNorihiko Ikeda

Abstract

We reviewed the medical record of a series of patients with synchronous multiple lung cancers (SMLC), in an attempt to identify the optimal treatment strategy for multiple ground-glass opacities (GGOs). From 2004 to 2010, 1223 patients underwent complete resection of non-small cell lung cancer. Among these, there were 67 patients (5.5%) with SMLC with at least 1 of the nodules showing GGO appearance. SMLC was divided into the main cancer (MC) which was a main target based on its tumor size or radiological invasiveness and sub-nodules. According to consolidation/tumor ratio (CTR) on thin-section computed tomography, 67 cases were classified into GG-group (MC showing GGO-dominant lesion; CTR≤0.5) and GS-group (MC showing solid-dominant lesion; CTR>0.5). There were 24 patients in the GG-group (36%) and 43 patients in the GS-group (64%). Surgical resections included 11 sublobar resections (SLs), 32 lobectomies, 19 lobectomy+SLs, and 4 bilobectomies. There were 39 patients with a total of 118 unresected GGOs after the initial surgery. Among them, the frequency of growth was 8% on a per-nodule basis with the median tumor doubling time of 1373 days, and new GGOs emerged in 15 patients (23%). Multivariate analysis demonstrated that lar...Continue Reading

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Citations

Nov 28, 2015·Journal of Cancer Research and Therapeutics·Yi-Feng ZhengZhi-Qiang Han
Apr 2, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ming LiuGe-Ning Jiang
May 31, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rowena YipClaudia I Henschke
Jun 3, 2016·Scientific Reports·Zhirong ZhangJie He
Oct 4, 2017·Japanese Journal of Clinical Oncology·Takeshi MatsunagaShiaki Oh
Jun 24, 2020·Journal of Cardiothoracic Surgery·Takamasa HottaTakeshi Isobe
Oct 30, 2020·Cancer Management and Research·Lishu ZhaoChunhong Hu
Oct 9, 2019·The Annals of Thoracic Surgery·Aritoshi HattoriKenji Suzuki

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