Survival of children with a Wilms tumor in Blantyre, Malawi

Pediatric Hematology and Oncology
Trijn IsraelsElizabeth M Molyneux

Abstract

Wilms tumor (WT) has a survival rate above 90% in high income countries. Reported survival rates in sub-Saharan Africa are much lower and long-term outcome is not well known as follow-up is challenging. In Blantyre, Malawi, an adapted WT treatment guideline with preoperative chemotherapy, supportive care, and strategies to enable children and parents to complete treatment was introduced in 2006. Between 2006 and 2011, 73 children with a unilateral WT were treated. Follow-up, including home visits when needed, was done. Median follow-up time is 5 years (range 14-95 months). Two and five-year event free survivals are 46 and 42%. Causes of treatment failure are: 7% (5/73) abandonment of treatment, 15% (11/73) death during treatment and 30% (22/73) disease-related deaths (persistent disease and relapse). Long-term follow-up is challenging but necessary to be able to assess outcome and the true impact of interventions.

References

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Apr 4, 2008·Pediatric Blood & Cancer·Dafalla O AbuidrisRamandeep S Arora
Sep 29, 2011·Pediatric Blood & Cancer·Trijn Israels
Jul 7, 2012·Journal of Pediatric Hematology/oncology·Trijn IsraelsElizabeth M Molyneux
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Nov 3, 2017·Journal of Global Oncology·Festus NjugunaSaskia Mostert

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Citations

Nov 9, 2019·Pediatric Surgery International·Sharon CoxAlastair J W Millar
May 12, 2020·Pediatric Blood & Cancer·George ChagalukaTrijn Israels
Sep 11, 2020·Pediatric Blood & Cancer·Sebastian O EkenzeIkenna I Nnabugwu
Mar 16, 2019·Science·Catherine G LamKathy Pritchard-Jones
Aug 4, 2020·Pediatric Blood & Cancer·Clayton B HessNatia Esiashvili
Feb 13, 2021·Journal of Pediatric Surgery·Henry DrysdaleKokila Lakhoo

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