Survival of children with neuroblastoma. time trends and regional differences in Europe, 1978--1992

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
C SpixJ Michaelis

Abstract

Neuroblastoma is one of the most common solid cancers in children. We present the data collected for the EUROCARE II study, describing survival patterns for children diagnosed in Europe 1985--1989 in detail, and exploring time trends from 1978 to 1992. On average, the mean 5-year survival rate was considerably higher in infants (79%) compared with older children (30--33%). The risk of death has dropped by 37% from 1978--1981 to 1990--1992. There is a pronounced difference between countries, with Scotland and England and Wales having two of the lowest survival rates (28% (95% confidence interval (CI) 14--48) and 36% (95% CI 31--41) 5-year survival rates, respectively). The survival rates in France, Germany and Italy (48--66% 5-year survival rate) were among the highest. This pattern corresponds to the incidence rates for these countries. It can be assumed that in neuroblastoma, both incidence and survival are related to the frequency of diagnosing asymptomatic cases with good prognosis among infants. However, one cannot ignore possible intercountry differences in the effectiveness of therapy.

Citations

Sep 5, 2002·Medical and Pediatric Oncology·Tatjana Burkhardt-HammerJörg Michaelis
Oct 4, 2005·Pediatric Blood & Cancer·Mara A D PianovskiBonald C Figueiredo
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Riccardo HauptBruno De Bernardi
Apr 5, 2002·The New England Journal of Medicine·Freimut H SchillingJoerg Michaelis
Jan 23, 2009·Paediatric and Perinatal Epidemiology·Julia E HeckPaolo Boffetta
Dec 2, 2015·Oncology Letters·Youssef Al-TonbaryAhmad Darwish
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thorsten SimonFrank Berthold
Aug 16, 2008·Molecular BioSystems·Paul BrennanSaman Hewamana
May 28, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Henriette Ingrid MelzerThomas Pfluger
Mar 15, 2006·Pediatric Blood & Cancer·Reinhold KerblPeter F Ambros
Sep 4, 2003·Statistics in Medicine·Claudia SpixFreimut H Schilling
Jan 17, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Zarah Glad ZimlingBodil Laub Petersen

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