PMID: 9524621Apr 3, 1998Paper

Survival of exclusively irradiated patients with NSCLC. Significance of pretherapeutic hemoglobin level

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
R WilhelmBernhard N Kimmig

Abstract

In a retrospective study files of 96 non-operated, non-small-cell lung cancer (NSCLC) patients receiving radiation therapy were statistically analysed. A correlation of the pre-therapeutical haemoglobin level and the survival of patients after a primary radiation therapy has been described by some authors, but it is an open question whether there is any dose-modification in the treatment schedule, related to different prognostic subgroups of patients, that makes sense. We have analysed the files of 96 primary radiated patients to evaluate the pre-therapeutical haemoglobin level as well as sex, age, histopathology, total dose and fractionation. The analysis of Karnofsky-status or patient condition was not performed as there was a lack of sufficient data in the patient files. Histopathology, sex, age as well as total dose and fractionation of the radiation treatment were similar in the cohort building 3 groups: Hb < 11 g/dl, Hb between 11 to 15 g/dl and Hb > 15 g/dl. The investigation resulted in the observation, that lower levels of initial serum haemoglobin concentration compared to levels over 15 g/dl are negative prognostic factors. Higher initial haemoglobin concentration is a high significant positive prognostic factor (p =...Continue Reading

References

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Citations

Feb 24, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Connie YipGary J R Cook
Dec 14, 2004·The Oncologist·Clifford A HudisKarsten Muenstedt

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