Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies

The Lancet. HIV
Antiretroviral Therapy Cohort Collaboration

Abstract

Health care for people living with HIV has improved substantially in the past two decades. Robust estimates of how these improvements have affected prognosis and life expectancy are of utmost importance to patients, clinicians, and health-care planners. We examined changes in 3 year survival and life expectancy of patients starting combination antiretroviral therapy (ART) between 1996 and 2013. We analysed data from 18 European and North American HIV-1 cohorts. Patients (aged ≥16 years) were eligible for this analysis if they had started ART with three or more drugs between 1996 and 2010 and had at least 3 years of potential follow-up. We estimated adjusted (for age, sex, AIDS, risk group, CD4 cell count, and HIV-1 RNA at start of ART) all-cause and cause-specific mortality hazard ratios (HRs) for the first year after ART initiation and the second and third years after ART initiation in four calendar periods (1996-99, 2000-03 [comparator], 2004-07, 2008-10). We estimated life expectancy by calendar period of initiation of ART. 88 504 patients were included in our analyses, of whom 2106 died during the first year of ART and 2302 died during the second or third year of ART. Patients starting ART in 2008-10 had lower all-cause mor...Continue Reading

Citations

Mar 14, 2018·Disability and Rehabilitation·Heather deBoerKelly K O'Brien
Feb 15, 2018·Healthcare·Padraig McGettrickPatrick W G Mallon
Mar 30, 2018·Expert Review of Clinical Pharmacology·Laura Benítez-GutiérrezCarmen de Mendoza
Nov 16, 2017·AIDS Research and Human Retroviruses·Gema Méndez-LagaresDennis J Hartigan-O'Connor
Dec 15, 2017·Frontiers in Microbiology·Melissa J BlumenthalGeorgia Schäfer
May 16, 2018·Infectious Diseases and Therapy·Anita ChawlaCorklin Steinhart
Mar 8, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sergio CarmonaWilliam B MacLeod
May 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sergio Serrano-VillarVicente Estrada
Feb 24, 2018·International Journal of STD & AIDS·Sam Rowlands, Jean-Jacques Amy
Jan 10, 2018·Journal of Endocrinological Investigation·F S MirzaL Chirch
Nov 15, 2017·Antimicrobial Agents and Chemotherapy·Payal P KakadiyaPatricia Pecora Fulco
Oct 11, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Charles AwortweHenrike Bruckmueller
Jul 26, 2018·Journal of the International AIDS Society·Françoise Barré-SinoussiPeter Godfrey-Faussett
Jul 29, 2018·AIDS and Behavior·Lori A J Scott-SheldonMichael P Carey
Aug 4, 2018·The Annals of Pharmacotherapy·Jamielynn C Sebaaly, Denise Kelley
Jan 10, 2018·Rapid Communications in Mass Spectrometry : RCM·Nhi PhungHoward Horng
May 17, 2018·Journal of Crohn's & Colitis·Christopher A LambEugene C Butcher
Sep 1, 2018·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Tanvi RaiHelen Ward
Jul 10, 2018·AIDS Research and Human Retroviruses·Rachel H SafeekMehri S McKellar
Sep 25, 2018·Pharmacoepidemiology and Drug Safety·Kedar JoshiSanjay Pujari
Mar 15, 2018·Circulation·Joshua A BeckmanMatthew S Freiberg
Sep 12, 2018·The Journal of Infectious Diseases·Jan KehrmannUNKNOWN HIV-HEART Study Group
Aug 23, 2018·AIDS·Annegret Pelchen-MatthewsUNKNOWN EuroSIDA study
Sep 14, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kennedy NkhomaRichard Harding
Sep 14, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Andreas RonitSusanne D Nielsen
Sep 12, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julien LupoCaroline Besson
Aug 29, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Adriana AmmassariUNKNOWN and the NEAT 001/ANRS 143 Trial Study Group
Jan 9, 2019·HIV Medicine·R BijkerUNKNOWN TREAT Asia HIV Observational Database (TAHOD) of IeDEA Asia-Pacific
Jan 24, 2019·Journal of the International Association of Providers of AIDS Care·Hartmut KrentzJohn Gill
Oct 31, 2018·American Journal of Respiratory Cell and Molecular Biology·Elya A ShamskhouVinicio A de Jesus Perez
Feb 14, 2019·Drugs·Dan PughNeeraj Dhaun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Cancer Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in Eu
© 2022 Meta ULC. All rights reserved