PMID: 7541529Jul 1, 1995Paper

Survival of human prostate carcinoma, benign hyperplastic prostate tissues, and IL-2-activated lymphocytes in scid mice

The Prostate
D M LubaroffW G Beamer

Abstract

Mice, homozygous for the mutation severe combined immunodeficiency (scid) and also segregating for the mutation hypogonadal (hpg), were tested for their potential use as an in vivo model system for studying the growth of human prostate cancer and benign hyperplastic prostate tissue grafts. Fresh human prostate cancer or benign hyperplastic prostate tissue was implanted subcutaneously into androgen-replete C.B. 17 scid/scid males, and into androgen-deficient hpg/hpg scid/scid or androgen-replete +/? scid scid males. The tissue grafts grew in both androgen-replete and androgen-deficient host mice. When dihydrotestosterone (DHT) was administered at tissue grafting, both the incidence and size of the tissue grafts increased. Histology of tissue from tumors in the androgen-deficient hpg/hpg scid/scid host showed either undifferentiated tumors or adenocarcinomas with few glandular structures. These data suggest the androgen deficient environment selected for growth of androgen-independent tumor tissue. Finally, when interleukin-2 (IL-2)-activated tumor-infiltrating lymphocytes were injected into scid/scid hosts, the cells were found to survive and could be identified in the spleen of the recipient mice. These results indicate that gr...Continue Reading

References

Jan 1, 1992·Epidemiologic Reviews·H A Guess
Mar 1, 1992·Transplantation·J L TaupinJ H Bezian
Jan 22, 1990·Molecular and Cellular Endocrinology·C LabrieF Labrie
Feb 10, 1983·Nature·G C BosmaM J Bosma
Jan 1, 1994·CA: a Cancer Journal for Clinicians·C C BoringS Montgomery

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Citations

Jun 29, 2001·Trends in Immunology·R B BankertS D Hess
Apr 7, 2010·Asian Journal of Andrology·Lluis A Lopez-Barcons
Dec 1, 2009·Asian Journal of Andrology·Lluis-A Lopez-Barcons
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Oct 1, 1996·Dermatologic Clinics·J P Sundberg, L E King
Jun 14, 2016·BioMed Research International·Domenica ReaClaudio Arra
Sep 13, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuwei WangYu-Zhuo Wang
Oct 17, 1998·Methods : a Companion to Methods in Enzymology·P G PiattiL P Villarreal
Feb 1, 1996·The Journal of Investigative Dermatology·J P Sundberg, L E King

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