PMID: 9440865Jan 24, 1998Paper

Survival of nigral grafts within the striatum of marmosets with 6-OHDA lesions depends critically on donor embryo age

Cell Transplantation
L E AnnettS B Dunnett

Abstract

The study examined the importance of embryonic donor age for the survival of nigral grafts in 6-OHDA-lesioned marmosets. The issue as to whether donor age is critical for the survival of nigral grafts in primates is controversial, because several early reports suggested that relatively old tissue could survive transplantation and produce functional benefits in monkeys, in contrast to the restrictive time dependence observed in rodents. Embryonic marmoset donors embryos of three different ages were employed: 1) E74 (Carnegie stage 18-19); 2) E83-84 (Carnegie stage 23+); 3) E92-93 (foetal period). The nigral neurons derived from the ventral mesencephalon in the two older donor age groups did not survive well when grafted to the striatum of adult marmosets with unilateral 6-OHDA lesions. Although a few tyrosine hydroxylase (TH+) neurons could be identified by immunohistochemistry at graft sites in all recipients in older donor age groups, the numbers of surviving neurons in these were small, on average typically less than 100 TH+ cells. These small grafts were not sufficient to affect amphetamine-induced rotation. In contrast, many more TH+ cells typically survived transplantation in the recipients of graft tissue derived from the...Continue Reading

Citations

Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jordi BovéSerge Przedborski
Oct 15, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Curt R FreedRobert E Breeze
Jan 30, 2016·The International Journal of Neuroscience·Bangfu ZhuBing Song
Mar 27, 2015·Parkinson's Disease·Philippe HuotJonathan M Brotchie
Feb 27, 2004·The European Journal of Neuroscience·Rosemary A Fricker-GatesStephen B Dunnett
Apr 27, 2012·Journal of Biomedicine & Biotechnology·Javier BlesaSerge Przedborski
Jun 8, 2001·Progress in Retinal and Eye Research·R D LundJ M Lawrence
Oct 19, 2004·Journal of Neuroscience Methods·Marina E Emborg

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