Survival of patients with documented autologous recovery after SCT for severe aplastic anemia: a study by the WPSAA of the EBMT

Bone Marrow Transplantation
A PiccinAplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation

Abstract

Graft rejection, with persistent pancytopenia, is well documented after allogeneic BMT (hematopoietic SCT (HSCT)) for severe aplastic anemia (SAA) and the prognosis is poor. The recovery of host-hematopoiesis, autologous recovery (AR), after allogeneic HSCT is a rare event and the incidence and long-term survival are unknown. We report a retrospective analysis of consecutive patients in the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT-WPSAA) registry between 1973 and 2005. A total of 45 cases of AR, of 1205 patients transplanted for SAA in 57 centers are reported. We describe characteristics and long-term outcome of patients with AR, compared with SAA patients from participating transplant centers without AR (n=1024) and patients with graft rejection (n=136) without autologous recovery. The estimated cumulative incidence of AR was 4.2% (3.1-5.6) (confidence interval (CI) 95%) with an OS of 84% (95% CI 83-107%). The OS of the control group was 74% (81-90) at 10 years of follow up, whereas the patients with graft failure had an OS of 16% (CI 12-28%). This retrospective analysis establishes the incidence and long-term survival of patients experiencing AR after allogeneic HSCT for ...Continue Reading

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Citations

Oct 16, 2012·Current Hematologic Malignancy Reports·Aaron T Gerds, Bart L Scott
Apr 19, 2011·Expert Review of Hematology·Amy E Dezern, Robert A Brodsky
Aug 26, 2015·British Journal of Haematology·Simone CesaroUNKNOWN Severe Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation
Apr 1, 2015·British Journal of Haematology·Qingguo LiuJianxiang Wang
Oct 22, 2016·Journal of Pediatric Hematology/oncology·Christopher J GamperRobert A Brodsky
Jan 18, 2017·Blood·Andrea Bacigalupo
Jul 6, 2018·British Journal of Haematology·Lucio Luzzatto, Antonio M Risitano
Nov 10, 2013·Immunologic Research·Wendy WestonRoland Jurecic
Dec 11, 2019·Bone Marrow Transplantation·Motohiro KatoUNKNOWN Transplantation Complication Working Group of the Japan Society for Hematopoietic Cell Transplantation
Mar 13, 2020·Bone Marrow Transplantation·Shaun McCann
Nov 17, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Abigail ShawUNKNOWN Aplastic Anaemia Working Party of the European Society for Blood and Marrow Transplantation
Sep 20, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Leonardo Javier ArcuriCarmem Bonfim

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