Abstract
Graft rejection, with persistent pancytopenia, is well documented after allogeneic BMT (hematopoietic SCT (HSCT)) for severe aplastic anemia (SAA) and the prognosis is poor. The recovery of host-hematopoiesis, autologous recovery (AR), after allogeneic HSCT is a rare event and the incidence and long-term survival are unknown. We report a retrospective analysis of consecutive patients in the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT-WPSAA) registry between 1973 and 2005. A total of 45 cases of AR, of 1205 patients transplanted for SAA in 57 centers are reported. We describe characteristics and long-term outcome of patients with AR, compared with SAA patients from participating transplant centers without AR (n=1024) and patients with graft rejection (n=136) without autologous recovery. The estimated cumulative incidence of AR was 4.2% (3.1-5.6) (confidence interval (CI) 95%) with an OS of 84% (95% CI 83-107%). The OS of the control group was 74% (81-90) at 10 years of follow up, whereas the patients with graft failure had an OS of 16% (CI 12-28%). This retrospective analysis establishes the incidence and long-term survival of patients experiencing AR after allogeneic HSCT for ...Continue Reading
References
Feb 6, 1988·Lancet·B M Camitta
Feb 26, 1999·Bone Marrow Transplantation·H C RossbachJ L Barbosa
Aug 30, 2000·Medical Oncology·J P Dutcher
Dec 3, 2003·Bone Marrow Transplantation·W HoelleP Bader
Mar 2, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Shaun R McCannMark Lawler
Oct 6, 2005·Bone Marrow Transplantation·A BacigalupoUNKNOWN Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
May 11, 2006·Blood·H Joachim DeegBarry Storer
Jul 22, 2006·Transplantation·Martin SternUNKNOWN Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
Nov 25, 2006·Hematology·Neal S Young
Dec 19, 2006·Bone Marrow Transplantation·S McCannM Lawler
Jan 19, 2007·Haematologica·Judith C W Marsh
Jan 19, 2007·Haematologica·Anna LocasciulliUNKNOWN Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplant Group
Feb 3, 2007·Blood·Richard E ChamplinMary M Horowitz
Feb 3, 2009·British Journal of Haematology·Mark LawlerUNKNOWN Severe Aplastic Anaemia Working Party of the European Blood and Marrow Transplant Group
Citations
Oct 16, 2012·Current Hematologic Malignancy Reports·Aaron T Gerds, Bart L Scott
Jan 18, 2011·Hematology·Jakob R Passweg, Judith C W Marsh
Apr 19, 2011·Expert Review of Hematology·Amy E Dezern, Robert A Brodsky
Aug 26, 2015·British Journal of Haematology·Simone CesaroUNKNOWN Severe Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation
Apr 1, 2015·British Journal of Haematology·Qingguo LiuJianxiang Wang
Jun 30, 2015·Bone Marrow Transplantation·K KudoS Kojima
Jun 10, 2011·Blood·Jean E SandersRainer F Storb
Oct 22, 2016·Journal of Pediatric Hematology/oncology·Christopher J GamperRobert A Brodsky
Jan 18, 2017·Blood·Andrea Bacigalupo
Jul 6, 2018·British Journal of Haematology·Lucio Luzzatto, Antonio M Risitano
Nov 10, 2013·Immunologic Research·Wendy WestonRoland Jurecic
Dec 11, 2019·Bone Marrow Transplantation·Motohiro KatoUNKNOWN Transplantation Complication Working Group of the Japan Society for Hematopoietic Cell Transplantation
Jun 17, 2020·Internal Medicine·Ayumi GomyoYoshinobu Kanda
Mar 13, 2020·Bone Marrow Transplantation·Shaun McCann
Nov 17, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Abigail ShawUNKNOWN Aplastic Anaemia Working Party of the European Society for Blood and Marrow Transplantation
Jun 16, 2021·Journal of Korean Medical Science·Jun Hong ParkKyoo Hyung Lee
Sep 20, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Leonardo Javier ArcuriCarmem Bonfim