Abstract
Once small (<10 mm) nodules, suspicious for hepatocellular carcinoma, are detected in cirrhotics, the European Association for the Study of the Liver guidelines recommend to delay histological confirmation and treatment until they increase in size. To validate this policy by evaluating survival of 450 cirrhotics in Child-Pugh class A or B with unifocal 'early' hepatocellular carcinoma treated by percutaneous alcohol injection. Patients were sorted by nodular size into three groups: < or =10 mm (n = 36, group A), >10 to < or = 20 mm (n = 142, group B) and >20 to < or = 30 mm (n = 272, group C). Overall and tumour-free survivals were estimated by Kaplan-Meier method. In groups A, B and C, mean follow-up was 33 +/- 26, 34 +/- 22 and 35 +/- 25 months (P = 0.89), mean survival time was 63 +/- 54, 57 +/- 48 and 62 +/- 66 months (P = 0.69) and mean tumour-free survival was 44 +/- 47, 46 +/- 58 and 41 +/- 68 months (P = 0.51), respectively. When patients were sorted by Child status, mean survival time was 76 +/- 82 and 38 +/- 29 months in Child A and B (P < 0.0001). The comparable survival of percutaneous alcohol injection-treated patients with single, early hepatocellular carcinoma sorted by nodular size supports the European Associat...Continue Reading
References
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L BarbaraA Mazziotti
Apr 1, 1990·Digestive Diseases and Sciences·G L RapacciniC Rabitti
Sep 1, 1990·AJR. American Journal of Roentgenology·S ShiinaT Sugimoto
Nov 1, 1990·Journal of Hepatology·L BuscariniA Salmi
Aug 1, 1985·Gastroenterology·J C SheuT H Wang
Feb 1, 1986·Gastroenterology·M EbaraK Okuda
Nov 1, 1989·Digestive Diseases and Sciences·C BruJ Rodés
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Jan 8, 2000·Hematology/oncology Clinics of North America·J P Fermand, J C Brouet
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Oct 11, 2001·Journal of Hepatology·J BruixUNKNOWN EASL Panel of Experts on HCC
Sep 27, 2002·Cardiovascular and Interventional Radiology·Eugenio CaturelliMichele Bisceglia
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eugenio CaturelliMarcello Anti
Mar 26, 2004·Journal of Cancer Research and Clinical Oncology·Bo-Heng ZhangZhao-You Tang
Apr 2, 2004·Gastroenterology·Angelo SangiovanniMassimo Colombo
Aug 13, 2004·Gut·J Schölmerich, D Schacherer
Aug 13, 2004·Gut·E CaturelliI de Sio
Oct 28, 2004·Gastroenterology·Ju-Seog Lee, Snorri S Thorgeirsson