Survival of proper hepatic artery lymph node metastasis in patients with gastric cancer: implications for D2 lymphadenectomy

PloS One
Cai ShirongHe Yulong

Abstract

There is a discrepancy between the American Joint Committee on Cancer (AJCC) guidelines (7th edition) and the Japanese treatment guidelines (3rd edition) with regard to the extent of D2 lymphadenectomy for gastric cancer. In the AJCC, hepatic artery station (No.12a) lymph node (LN) metastasis is classified as distant metastasis, whereas in the Japanese guidelines, this classified is regional metastasis. This study aimed to evaluate whether it is appropriate to reclassify No.12a LN metastasis as distant metastasis in consideration of survival outcome. In this retrospective analysis, data from patients with gastric cancer who underwent regular D2 or greater lymphadenectomy between 1996 and 2006 were evaluated to determine any association between the clinicopathological features of hepatic artery LNs and survival prognosis. Among the 247 patients with gastric cancer who underwent No.12 LN harvest, 45 (18.2%) were positive for No.12a LN metastasis. No.12a LN metastasis was significantly associated with poor clinicopathological features, advanced tumor stage, and poor overall survival. The 5-year survival rate of patients with No.12a LN metastasis was significantly better than that of patients with distant metastasis (P < 0.05), but...Continue Reading

References

Jan 27, 2011·World Journal of Gastrointestinal Oncology·Markus Menges
Dec 15, 2011·Annals of Surgery·Daniele MarrelliUNKNOWN Italian Research Group for Gastric Cancer (IRGGC)
Jun 15, 2013·Critical Reviews in Oncology/hematology·Richard KimBassel F El-Rayes
Jan 1, 2014·The British Journal of Surgery·M DegiuliUNKNOWN Italian Gastric Cancer Study Group
Mar 13, 2014·The British Journal of Surgery·S L LeeS S Kim

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Citations

Jul 26, 2016·Molecular and Clinical Oncology·Yongjian HuangJianxin Ye
Apr 26, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ji Hoon KangOh Jeong

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